Quantitative measurement of feline colonic transit

Krevsky, B; Somers, M B; Maurer, A H; Malmud, L S; Knight, L C; Fisher, R S

Title: Quantitative measurement of feline colonic transit

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Abstract

Colonic transit scintigraphy, a method for quantitatively evaluating the movement of the fecal stream in vivo, was employed to evaluate colonic transit in the cat. Scintigraphy was performed in duplicate in five cats and repeated four times in one cat. After instillation of an 111In marker into the cecum through a surgically implanted silicone cecostomy tube, colonic movement of the instillate was quantitated for 24 h using gamma scintigraphy. Antegrade and retrograde motion of radionuclide was observed. The cecum and ascending colon emptied rapidly, with a half-emptying time of 1.68 +/- 0.56 h (mean +/- SE). After 24 h, 25.1 +/- 5.2% of the activity remained in the transverse colon. The progression of the geometric center was initially rapid, followed later by a delayed phase. Geometric center reproducibility was found to be high when analyzed using simple linear regression (slope = 0.92; r = 0.73; P less than 0.01). Atropine (0.1 mg/kg im) was found to delay cecum and ascending colon emptying and delay progression of the geometric center. These results demonstrate both 1) the ability of colonic transit scintigraphy to detect changes in transit induced by pharmacological manipulation and 2) the fact that muscarinic blockade inhibits antegrade transit ofmore »« less

Authors:: Krevsky, B; Somers, M B; Maurer, A H; Malmud, L S; Knight, L C; Fisher, R S

Publication Date:: Sat Oct 01 00:00:00 EDT 1988

Research Org.:: Temple Univ. School of Medicine, Philadelphia, PA (USA)

OSTI Identifier:: 6604322

Resource Type:: Journal Article

Journal Name:: Am. J. Physiol.; (United States)

Additional Journal Information:: Journal Volume: 255

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; ATROPINE; BIOLOGICAL EFFECTS; LARGE INTESTINE; SCINTISCANNING; CATS; DYNAMIC FUNCTION STUDIES; FECES; INDIUM 111; REGRESSION ANALYSIS; ALKALOIDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GASTROINTESTINAL TRACT; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; INTESTINES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MATHEMATICS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PARASYMPATHOLYTICS; RADIOISOTOPE SCANNING; RADIOISOTOPES; STATISTICS; VERTEBRATES; WASTES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Krevsky, B, Somers, M B, Maurer, A H, Malmud, L S, Knight, L C, and Fisher, R S. Quantitative measurement of feline colonic transit.  United States: N. p., 1988. 
        Web.

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                    Krevsky, B, Somers, M B, Maurer, A H, Malmud, L S, Knight, L C, & Fisher, R S. Quantitative measurement of feline colonic transit.  United States.

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                    Krevsky, B, Somers, M B, Maurer, A H, Malmud, L S, Knight, L C, and Fisher, R S. 1988.  
        "Quantitative measurement of feline colonic transit".  United States.

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@article{osti_6604322,

  title        = {Quantitative measurement of feline colonic transit},

  author       = {Krevsky, B and Somers, M B and Maurer, A H and Malmud, L S and Knight, L C and Fisher, R S},

  abstractNote = {Colonic transit scintigraphy, a method for quantitatively evaluating the movement of the fecal stream in vivo, was employed to evaluate colonic transit in the cat. Scintigraphy was performed in duplicate in five cats and repeated four times in one cat. After instillation of an 111In marker into the cecum through a surgically implanted silicone cecostomy tube, colonic movement of the instillate was quantitated for 24 h using gamma scintigraphy. Antegrade and retrograde motion of radionuclide was observed. The cecum and ascending colon emptied rapidly, with a half-emptying time of 1.68 +/- 0.56 h (mean +/- SE). After 24 h, 25.1 +/- 5.2% of the activity remained in the transverse colon. The progression of the geometric center was initially rapid, followed later by a delayed phase. Geometric center reproducibility was found to be high when analyzed using simple linear regression (slope = 0.92; r = 0.73; P less than 0.01). Atropine (0.1 mg/kg im) was found to delay cecum and ascending colon emptying and delay progression of the geometric center. These results demonstrate both 1) the ability of colonic transit scintigraphy to detect changes in transit induced by pharmacological manipulation and 2) the fact that muscarinic blockade inhibits antegrade transit of the fecal stream. We conclude that feline colonic transit may be studied in a quantitative and reproducible manner with colonic transit scintigraphy.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6604322},
  journal      = {Am. J. Physiol.; (United States)},
number       = ,

  volume       = 255,

  place        = {United States},

  year         = {Sat Oct 01 00:00:00 EDT 1988},

  month        = {Sat Oct 01 00:00:00 EDT 1988}

}

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