Photodynamic therapy by topical meso-tetraphenylporphinesulfonate tetrasodium salt administration in superficial basal cell carcinomas

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Cancer Research; (USA)

OSTI ID:6602979

Santoro, O; Bandieramonte, G; Melloni, E; Marchesini, R; Zunino, F; Lepera, P; De Palo, G ^[1]

---

1. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan (Italy)

The efficacy of an originally developed photodynamic approach, using topical administration of tetraphenylporphinesulfonate as the photosensitizer, was evaluated in a series of 292 basal cell carcinoma lesions (less than 2-mm thick) in 50 treated patients. The lack of indication for conventional therapies was the main selection criterion. The photosensitizing agent (2% solution) was topically applied at 0.1 ml/cm2, followed by light irradiation with a dye laser emitting at 645 nm (120 or 150 J/cm2). After initial treatment, all lesions responded, with 273 (93.5%) complete responses. Recurrences were observed in 29 (10.6%). A second application of photoradiation was performed in 15 persistent lesions and 11 relapsed lesions, producing 19/26 complete responses. Our results suggest that this technique can be considered a promising alternative treatment modality in selected cases of superficial basal cell carcinomas.

• OSTI ID: 6602979
• Journal Information: Cancer Research; (USA), Vol. 50:15; ISSN 0008-5472
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
THERAPY
LASER RADIATION
BIOLOGICAL EFFECTS
SKIN
BIOPSY
DYE LASERS
MAN
PHOTOSENSITIVITY
PORPHYRINS
ANIMALS
BODY
CARBOXYLIC ACIDS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LASERS
LIQUID LASERS
MAMMALS
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
RADIATIONS
SENSITIVITY
VERTEBRATES
560400* - Other Environmental Pollutant Effects
550600 - Medicine