Pulmonary function and symptom responses after 6. 6-hour exposure to 0. 12-ppm ozone with moderate exercise (journal version)
Episodes occasionally occur when ambient ozone (O/sub 3/) levels remain at or near 0.12 ppm for more than 6 h. The hypothesis that prolonged exposure to 0.12 ppm O/sub 3/ would result in progressively larger changes in respiratory function and symptoms over time was tested. Ten nonsmoking males (18-35 yr) were exposed once to clear air (CA) and once to 0.12 pp, O/sub 3/ for 6.75 h. Exposures consisted of six 50-min exercise periods, each followed by 10-min rest and measurement; a 45-min lunch period followed the third exercise period. Exercise ventilation averaged approximately 40 1/min. Forced expiratory and inspiratory spirometry and respiratory symptoms were measured prior to exposure and after each exercise. Increases in the symptom ratings of cough and pain on deep inspiration were observed with O/sub 3/ exposure but not with CA. Airway reactivity to methacholine was approximately doubled following O/sub 3/ exposure. Spirometry results indicate that prolonged exposure to 0.12 ppm O/sub 3/ results in a marked increase in non-specific airway reactivity and progressive changes in respiratory function.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 6600937
- Report Number(s):
- PB-89-110308/XAB; EPA-600/J-88/052
- Resource Relation:
- Other Information: Pub. in Jnl. of the Air Pollution Control Association, Vol. 38, No. 1, 28-35(Jan 1988)
- Country of Publication:
- United States
- Language:
- English
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