Effects of X irradiation on the cytoskeleton of rat alveolar macrophages in vitro
The three-dimensional visualization of Triton X-100 resistant cytoskeletons has been used to demonstrate that an absorbed dose of 120 Gy from X rays causes a distinctive and reproducible alteration of the cytoskeleton of intact rat alveolar macrophages in vitro. The alteration has also been shown to be rapidly and completely ''repaired'' and to be apparently similar to alterations caused by colchicine but dissimilar to those caused by cytochalasin B. From these observations and those of other workers who have studied the irradiation of extracted microtubular proteins in vitro, the authors think it likely that microtubules rather than microfilaments are the radiosensitive component of the macrophage cytoskeleton.
- Research Organization:
- Medical Research Council, Harwell, England
- OSTI ID:
- 6597987
- Journal Information:
- Radiat. Res.; (United States), Vol. 99:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MACROPHAGES
BIOLOGICAL RADIATION EFFECTS
TRANSMISSION ELECTRON MICROSCOPY
MICROTUBULES
BIOLOGICAL REPAIR
IN VITRO
RATS
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
CELL CONSTITUENTS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
IONIZING RADIATIONS
MAMMALS
MICROSCOPY
PHAGOCYTES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RODENTS
SOMATIC CELLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)