Propylene oxide causes central-peripheral distal axonopathy in rats
Journal Article
·
· Arch. Environ. Health; (United States)
In Wistar rats subjected daily to a 6-hr exposure of propylene oxide (PO) at a concentration of 1,500 ppm (5 times a wk for 7 wk), ataxia developed in the hindlegs. Myelinated fibers in hindleg nerves and in the fasciculus gracilis showed axonal degeneration, sparing the nerve cell body of the first sacral dorsal root ganglion and myelinated fibers of the first sacral dorsal and ventral roots. These pathologic findings are compatible with central-peripheral distal axonopathy. This is apparently the first animal model of PO neuropathy to be verified histologically.
- Research Organization:
- Univ. of Occupational and Environmental Health, Kitakyushu (Japan)
- OSTI ID:
- 6597354
- Journal Information:
- Arch. Environ. Health; (United States), Vol. 43:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of lead on the developing peripheral nervous system. [Rats]
A comparison of peripheral and central axotomy effects on neurofilament and tubulin gene expression in rat dorsal root ganglion neurons
Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy
Journal Article
·
Sat Jul 01 00:00:00 EDT 1978
· J. Neuropathol. Exp. Neurol.; (United States)
·
OSTI ID:6597354
A comparison of peripheral and central axotomy effects on neurofilament and tubulin gene expression in rat dorsal root ganglion neurons
Journal Article
·
Sun Jul 01 00:00:00 EDT 1990
· Journal of Neuroscience; (USA)
·
OSTI ID:6597354
Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy
Journal Article
·
Mon May 01 00:00:00 EDT 2017
· Toxicology and Applied Pharmacology
·
OSTI ID:6597354
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NERVES
PATHOLOGICAL CHANGES
PROPYLENE
TOXICITY
AIR POLLUTION
BIOLOGICAL MODELS
RATS
ALKENES
ANIMALS
HYDROCARBONS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
POLLUTION
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
NERVES
PATHOLOGICAL CHANGES
PROPYLENE
TOXICITY
AIR POLLUTION
BIOLOGICAL MODELS
RATS
ALKENES
ANIMALS
HYDROCARBONS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
POLLUTION
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology