Adenocarcinoma of the stomach and exposure to occupational dust

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Am. J. Epidemiol.; (United States)

OSTI ID:6597086

Wright, W E; Bernstein, L; Peters, J M; Garabrant, D H; Mack, T M

The authors studied 1342 cases of adenocarcinoma of the stomach identified by a population-based cancer registry in Los Angeles County, California. The cases were males aged 20-64 years first diagnosed between 1972 and 1982. To determine whether exposure to occupational dust increased the risk of developing stomach cancer, occupational titles were rated for the likelihood of exposure to various kinds of dust. Men who worked in dusty jobs had a risk for developing stomach cancer 1.3 times that of unexposed men. The association of exposure to dust with stomach cancer was stronger at higher levels of exposure. The risk was not uniform throughout the stomach: the highest risk (1.8 times that of unexposed men) was found for the antrum/pylorus. At that site, exposure to mineral dust carried the greatest risk for cancer (3.7 times the risk for unexposed men). The highest risks from dust exposure were observed in blacks. Risk was related to race, socioeconomic status, and immigrant status, but these factors did not entirely explain the association with dust exposure. The observed relation between dust exposure and stomach cancer is consistent with results of previous mortality and case-control studies of cancer in men who worked in dusty occupations. Ingested dust may be one factor in the etiology of adenocarcinoma of the stomach.

• Research Organization: Univ. of Southern California School of Medicine, Los Angeles (USA)
• OSTI ID: 6597086
• Journal Information: Am. J. Epidemiol.; (United States), Vol. 128:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DUSTS
CARCINOGENESIS
HEALTH HAZARDS
EPIDEMIOLOGY
STOMACH
NEOPLASMS
AIR POLLUTION
ETIOLOGY
EXHAUST GASES
INGESTION
METALS
MINERALS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
RISK ASSESSMENT
BODY
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
FLUIDS
GASEOUS WASTES
GASES
GASTROINTESTINAL TRACT
HAZARDS
INTAKE
ORGANS
PATHOGENESIS
POLLUTION
WASTES
560300* - Chemicals Metabolism & Toxicology