New improved synthesis of 2-deoxy-2-(/sup 18/F)fluoro-d-glucose from /sup 18/F-labeled acetyl hypofluorite
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:6592002
- Brookhaven National Lab., Upton, NY
A new improved synthesis of 2-deoxy-2-(/sup 18/F)fluoro-D-glucose (2-/sup 18/FDG, 4) from /sup 18/F-labeled acetyl hypofluorite (1) is described. Reaction of 3,4,6-tri-O-acetyl-D-glucal (2) with 1, generated in situ from (/sup 18/F)F/sub 2/ and ammonium acetate in acetic acid solution at room temperature, gave 2-deoxy-2-(/sup 18/F)fluoro-1,3,4,6-tetra-O-acetyl-..cap alpha..-D-glucopyranose (3). Hydrolysis of compound 3 with 2N HCl gave 2-deoxy-2-(/sup 18/F)fluoro-D-glucose (4) in radiochemical yields of approx.20% in a synthesis time of 70 min from EOB.
- OSTI ID:
- 6592002
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:10
- Country of Publication:
- United States
- Language:
- English
Similar Records
Process for the production of /sup 18/F-2-deoxy-2-fluoro-d-glucose
Remote, semiautomated production of F-18-labeled 2-deoxy-2-fluoro-D-glucose
Electrophilic fluorinations with glycals. Effect of solvent and substrate on product distribution
Patent
·
·
OSTI ID:6592002
+2 more
Remote, semiautomated production of F-18-labeled 2-deoxy-2-fluoro-D-glucose
Journal Article
·
Wed Apr 01 00:00:00 EST 1981
· J. Nucl. Med.; (United States)
·
OSTI ID:6592002
+3 more
Electrophilic fluorinations with glycals. Effect of solvent and substrate on product distribution
Conference
·
Wed May 01 00:00:00 EDT 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:6592002
+1 more
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
HEXOSES
LABELLING
LABELLED COMPOUNDS
CHEMICAL PREPARATION
ORGANIC FLUORINE COMPOUNDS
ALDEHYDES
FLUORINE 18
GLUCOSE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
SACCHARIDES
SYNTHESIS
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
HEXOSES
LABELLING
LABELLED COMPOUNDS
CHEMICAL PREPARATION
ORGANIC FLUORINE COMPOUNDS
ALDEHYDES
FLUORINE 18
GLUCOSE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
SACCHARIDES
SYNTHESIS
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials