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Title: SPECT with I-123 labeled F(ab')/sub 2/ fragments from monoclonal anti-CEA antibodies in colon carcinoma

Abstract

Eleven patients with colorectal carcinoma were studied, 4 with primary, 7 with recurrent (1) or metastatic lesions. After injection of 1,5mg of F(ab')/sub 2/ of monoclonal anti-CEA antibodied No 35 (n=9) or 202 (n=2) labeled with I-123 (p,5n) (3-4mCi) whole body distribution was measured on anterior and posterior views at 1,6,24,48 h. SPECT was performed with a dual head device at 6,24,48 h. F(ab')/sub 2/ No 202 showed relatively high bone marrow uptake and high urinary activity (74% of injected activity in 3 days), but low liver activity (x-bar 14% of whole body activity at 24 h ). With F(ab')/sub 2/ No 35 bone marrow activity was lower, mean relative liver uptake 17% and mean urinary activity 24%. In 2 surgical specimens tumor to normal tissue ratios were measured at day 5 post injection and found to be 6,8,15,9 for one, 3,5,7,2 for the other in comparison with mucosa, serosa, fat and blood respectively. All 5 localized carcinoma were detected by ECT, the best images being obtained at 24 h. On the 6 h scans 4 patients with liver metastases showed cold lesions which became positive on the 24 h ECT in 2 of them whereas the 2 others remainedmore » doubtful. 2 patients with liver involvement showed no uptake. In 1 patient under therapy 2 small lung metastases were not detected. 2/2 bone metastases showed tracer uptake 1 of them was previously unknown. High quality images can be obtained with this method already at 24 h but the detection of metastases especially in the liver is sometimes difficult.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Ludwig Inst. for Cancer Research, Div. of Nucl. Medicine and Inst. of Biochemistry, Lausanne
OSTI Identifier:
6590592
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-018934
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; CARCINOMAS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; LARGE INTESTINE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; UPTAKE; ANTIBODIES; BONE MARROW; CARCINOEMBRYONIC ANTIGEN; IMAGES; INTRAVENOUS INJECTION; LABELLING; LIVER; MONOCLONAL ANTIBODIES; NEOPLASMS; PATIENTS; RADIONUCLIDE KINETICS; ANIMAL TISSUES; ANTIGENS; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DISTRIBUTION; DRUGS; EMISSION COMPUTED TOMOGRAPHY; GASTROINTESTINAL TRACT; GLANDS; HEMATOPOIETIC SYSTEM; INJECTION; INTAKE; INTESTINES; LABELLED COMPOUNDS; ORGANS; TISSUES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550501 - Metabolism- Tracer Techniques

Citation Formats

Delaloye, B, Bischof-Delaloye, A, Grob, J, Buchegger, F, Halpern, S, Von Fliedner, V, and Mach, J P. SPECT with I-123 labeled F(ab')/sub 2/ fragments from monoclonal anti-CEA antibodies in colon carcinoma. United States: N. p., 1984. Web.
Delaloye, B, Bischof-Delaloye, A, Grob, J, Buchegger, F, Halpern, S, Von Fliedner, V, & Mach, J P. SPECT with I-123 labeled F(ab')/sub 2/ fragments from monoclonal anti-CEA antibodies in colon carcinoma. United States.
Delaloye, B, Bischof-Delaloye, A, Grob, J, Buchegger, F, Halpern, S, Von Fliedner, V, and Mach, J P. 1984. "SPECT with I-123 labeled F(ab')/sub 2/ fragments from monoclonal anti-CEA antibodies in colon carcinoma". United States.
@article{osti_6590592,
title = {SPECT with I-123 labeled F(ab')/sub 2/ fragments from monoclonal anti-CEA antibodies in colon carcinoma},
author = {Delaloye, B and Bischof-Delaloye, A and Grob, J and Buchegger, F and Halpern, S and Von Fliedner, V and Mach, J P},
abstractNote = {Eleven patients with colorectal carcinoma were studied, 4 with primary, 7 with recurrent (1) or metastatic lesions. After injection of 1,5mg of F(ab')/sub 2/ of monoclonal anti-CEA antibodied No 35 (n=9) or 202 (n=2) labeled with I-123 (p,5n) (3-4mCi) whole body distribution was measured on anterior and posterior views at 1,6,24,48 h. SPECT was performed with a dual head device at 6,24,48 h. F(ab')/sub 2/ No 202 showed relatively high bone marrow uptake and high urinary activity (74% of injected activity in 3 days), but low liver activity (x-bar 14% of whole body activity at 24 h ). With F(ab')/sub 2/ No 35 bone marrow activity was lower, mean relative liver uptake 17% and mean urinary activity 24%. In 2 surgical specimens tumor to normal tissue ratios were measured at day 5 post injection and found to be 6,8,15,9 for one, 3,5,7,2 for the other in comparison with mucosa, serosa, fat and blood respectively. All 5 localized carcinoma were detected by ECT, the best images being obtained at 24 h. On the 6 h scans 4 patients with liver metastases showed cold lesions which became positive on the 24 h ECT in 2 of them whereas the 2 others remained doubtful. 2 patients with liver involvement showed no uptake. In 1 patient under therapy 2 small lung metastases were not detected. 2/2 bone metastases showed tracer uptake 1 of them was previously unknown. High quality images can be obtained with this method already at 24 h but the detection of metastases especially in the liver is sometimes difficult.},
doi = {},
url = {https://www.osti.gov/biblio/6590592}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}

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