Nuclear medicine progress report for quarter ending September 30, 1982
In this report a new kit is described for the rapid, regiospecific radioiodination of 15-(p-iodophenyl)pentadecanoic acid (IPP). Iodine-123-labeled IPP is used clinically to monitor myocardial fatty acid metabolism and the new kit offers a major improvement over present methods of radioiodination. During the period three shipments of /sup 191/Os-osmate were made to Medical Cooperative investigators for fabrication of the /sup 191/Os-/sup 191m/Ir radionuclide generator. Five production runs of /sup 11/C labeled amino acids including L-valine, DL-tryptophan and 1-aminocyclohexanecarboxylic acid were synthesized for clinical studies at the Oak Ridge Associated Universities. In addition, seven shipments of /sup 195m/Pt-cis-dichlorodiammineplatinum(II) were made to collaborators for evaluation of the pharmacologic properties of this antitumor agent and to monitor the effective therapeutic dose levels. Several /sup 125/I- and /sup 123m/Te-labeled fatty acids were prepared for evaluation in conjunction with collaborators at the Massachusetts General Hospital. Studies of radioiodinated barbiturates as potential new agents to measure cerebral blood perfusion have also continued. Iodine-125-labeled 5-ethyl-t-(meta-iodophenyl)barbituric acid was prepared as a model agent in which the iodine was stabilized by attachment to a phenyl ring. Evaluation in rats indicated brain uptake with only minimal deiodination. Preliminary studies with tritium-labeled benzo(a)pyrene have also been performed using Syrian hamster embryo (SHE) cells grown in diffusion chambers implanted in rats.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6585284
- Report Number(s):
- ORNL/TM-8533; ON: DE83005170
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NUCLEAR MEDICINE
RESEARCH PROGRAMS
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
AMINO ACIDS
BENZOPYRENE
CARBON 11
CARBOXYLIC ACIDS
IODINE 123
IODINE 125
LABELLING
OSMIUM 191
PLATINUM 195
TELLURIUM 123
TRITIUM
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON ISOTOPES
CONDENSED AROMATICS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
HYDROCARBONS
HYDROGEN ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OSMIUM ISOTOPES
PLATINUM ISOTOPES
RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics