Exposure of pharmacy personnel to mutagenic antineoplastic drugs

Technical Report · Thu Jan 01 00:00:00 EST 1981

OSTI ID:6582794

Nguyen, T V; Theiss, J C; Matney, T S

The Salmonella reversion test was used to measure the mutagenic activities of urine concentrates from individuals preparing cancer chemotherapy agents for intravenous administration. Longitudinal studies were performed in which the total urine produced in 24 hour periods was collected, starting on a Sunday at 7:00 p.m. after a duty-free weekend and extending over an eight day period. There was no detectable increase in mutagenic activity in the urine concentrates of three pharmacy administrators who had no contact with these drugs. All six individuals admixing drugs in open-faced, horizontal laminar flow hoods displayed a two-fold increase in mutagenesis by the fourth day with peak values of 2.7 to 24-fold occurring on days five and six, reduced values by day seven with a return to the spontaneous level by day eight. When four of the six positive individuals in the preceding experiment admixed comparable amounts of chemotherapeutic drugs in a closed-faced, vertical laminar flow hood, no increase in mutagenic activity was detected in their urine concentrates over the eight day period.

• Research Organization: Texas Univ., Houston (USA). Health Science Center
• DOE Contract Number: AS05-76EV04024
• OSTI ID: 6582794
• Report Number(s): DOE/EV/04024-T1; ON: DE83003400
• Resource Relation: Other Information: Portions of document are illegible
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MEDICAL PERSONNEL
OCCUPATIONAL SAFETY
URINE
MUTAGEN SCREENING
ANTINEOPLASTIC DRUGS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
DRUGS
MATERIALS
PERSONNEL
SAFETY
SCREENING
WASTES
550600* - Medicine
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)