Abnormal oral glucose tolerance and glucose malabsorption after vagotomy and pyloroplasty. A tracer method for measuring glucose absorption rates

Journal Article · Mon Nov 01 00:00:00 EST 1982 · Gastroenterology; (United States)

OSTI ID:6582628

Radziuk, J; Bondy, D C

The mechanisms underlying the abnormal glucose tolerance in patients who had undergone vagotomy and pyloroplasty were investigated by measuring the rates of absorption of ingested glucose and the clearance rate of glucose using tracer methods. These methods are based on labeling a 100-g oral glucose load with (1-/sup 14/C)glucose and measuring glucose clearance using plasma levels of infused (3-/sup 3/H)glucose. The rate of appearance of both ingested and total glucose is then calculated continuously using a two-compartment model of glucose kinetics. It was found that about 30% of the ingested glucose (100 g) failed to appear in the systemic circulation. That this was due to malabsorption was confirmed using breath-hydrogen analysis. The absorption period is short (101 +/- 11 min) compared with normal values but the clearance of glucose is identical to that in control subjects, and it peaks 132 +/- 7 min after glucose loading. The peak plasma insulin values were more than four times higher in patients than in normal subjects, and this may afford an explanation of rates of glucose clearance that are inappropriate for the short absorption period. The combination of glucose malabsorption and this clearance pattern could yield the hypoglycemia that may be observed in patients after gastric surgery.

• Research Organization: Department of Medicine, University Hospital, London, Ontario, Canada
• OSTI ID: 6582628
• Journal Information: Gastroenterology; (United States), Vol. 83:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GLUCOSE
BLOOD-PLASMA CLEARANCE
INTESTINAL ABSORPTION
SURGERY
SIDE EFFECTS
BLOOD CHEMISTRY
CARBON 14 COMPOUNDS
INSULIN
PATIENTS
STOMACH
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VAGUS
ABSORPTION
ALDEHYDES
AUTONOMIC NERVOUS SYSTEM
BODY
CARBOHYDRATES
CLEARANCE
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
HEXOSES
HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MEDICINE
MONOSACCHARIDES
NERVES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
SACCHARIDES
UPTAKE
550601* - Medicine- Unsealed Radionuclides in Diagnostics