Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: a Southwest Oncology Group study

Cruz, Jr, A B; Perkins, M; Aust, J B

doi:10.1002/jso.2930200410

Title: Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: a Southwest Oncology Group study

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Abstract

Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.

Authors:

Cruz, Jr, A B ^[1]; Perkins, M; Aust, J B

Univ of Texas, San Antonio

Publication Date:: Sun Aug 01 00:00:00 EDT 1982

OSTI Identifier:: 6581142

Resource Type:: Journal Article

Journal Name:: J. Surg. Oncol.; (United States)

Additional Journal Information:: Journal Volume: 20:4

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; BLEOMYCIN; BIOLOGICAL EFFECTS; CARCINOMAS; CHEMOTHERAPY; RADIOTHERAPY; HEAD; FRACTIONATED IRRADIATION; HYDROXYUREA; NECK; BIOLOGICAL RADIATION EFFECTS; COBALT 60; DOSE-RESPONSE RELATIONSHIPS; PATIENTS; SIDE EFFECTS; SURVIVAL CURVES; AMIDES; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BODY AREAS; COBALT ISOTOPES; DISEASES; DRUGS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATION EFFECTS; RADIOISOTOPES; RADIOLOGY; THERAPY; YEARS LIVING RADIOISOTOPES; 550603* - Medicine- External Radiation in Therapy- (1980-); 550600 - Medicine

Citation Formats


                    Cruz, Jr, A B, Perkins, M, and Aust, J B. Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: a Southwest Oncology Group study.  United States: N. p., 1982. 
        Web.  doi:10.1002/jso.2930200410.

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                    Cruz, Jr, A B, Perkins, M, & Aust, J B. Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: a Southwest Oncology Group study.  United States.  https://doi.org/10.1002/jso.2930200410

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                    Cruz, Jr, A B, Perkins, M, and Aust, J B. 1982.  
        "Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: a Southwest Oncology Group study".  United States.  https://doi.org/10.1002/jso.2930200410.

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@article{osti_6581142,

  title        = {Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: a Southwest Oncology Group study},

  author       = {Cruz, Jr, A B and Perkins, M and Aust, J B},

  abstractNote = {Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.},

  doi          = {10.1002/jso.2930200410},

  url          = {https://www.osti.gov/biblio/6581142},
  journal      = {J. Surg. Oncol.; (United States)},
number       = ,

  volume       = 20:4,

  place        = {United States},

  year         = {Sun Aug 01 00:00:00 EDT 1982},

  month        = {Sun Aug 01 00:00:00 EDT 1982}

}

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