Oxygen at 2 atmospheres absolute pressure does not increase the radiation sensitivity of normal brain in rats

Journal Article · Sun Jul 01 00:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90178-0· OSTI ID:6578683

Routh, A; Kapp, J P; Smith, E E; Bebin, J; Barnes, T; Hickman, B T

Cranial radiation was administered to CD Fisher rats at 1.0, 1.5 and 2.0 atmospheres oxygen pressure. Life span following radiation was recorded. Surviving animals were killed at 28 weeks and the brains were examined independently by two neuropathologists. Survival time was significantly less in animals receiving higher doses of radiation but showed no relationship to the oxygen pressure in the environment of the animal at the time radiation was administered. Microscopic examination of the brain did not reveal any differences in animals radiated in a normobaric or hyperbaric oxygen environment. It is concluded that hyperbaric oxygen does not sensitize the normal brain to the effects of ionizing radiation.

• Research Organization: Univ. of Mississippi School of Medicine, Jackson
• OSTI ID: 6578683
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:7
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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LIFE SPAN
OXYGEN
RADIOSENSITIVITY EFFECTS
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