17p deletions and chromosome 17 copy number correlate strongly with grade and stage in bladder cancer
- Univ. of California, San Francisco (United States)
- Univ. of Basel (Switzerland)
The clinical course of bladder cancer is not predicted by histological criteria along. Mutation at p53, usually accompanied by allelic loss on the other chromosome 17p, has been implicated as a prognostic parameter in several tumors, including bladder cancer. The authors therefore examined 153 bladder cancer samples by fluorescence in situ hybridization (FISH) to assess deletions on chromosome 17p. Probes for a pericentromeric region on 17 and a probe for the p53 locus were applied simultaneously. Prevalence of 17p deletion was lower in pTa (4/43), than in pT1 (20/42) or pT2-4 tumors (28/58) (p = 0.0001). There was also a strong correlation between 17p deletions and tumor grade. Average centromere 17 copy number was higher in pT1, than in pTa tumors (p = 0.0001) and correlated also with tumor grade, 17p deletions and p53 immunostaining (CM1). 17p deletions correlated with p53 immunostaining when all cases were considered (p = 0.0005) but not for the subgroup of T2-4 tumors. The findings suggest that p53 mutations as well as 17p deletions are early events in bladder cancer, appearing at the time of early invasion (pT1).
- OSTI ID:
- 6574643
- Report Number(s):
- CONF-9303114-; CODEN: CYTODQ
- Journal Information:
- Cytometry (Baltimore); (United States), Vol. 6; Conference: 16. congress of the International Society for Analytical Cytology, Colorado Springs, CO (United States), 21-26 Mar 1993; ISSN 0196-4763
- Country of Publication:
- United States
- Language:
- English
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