Localization of the human gene for inducible nitric oxide synthase (NOS2) to chromosome 17q11. 2-q12

Journal Article · Sat Jan 01 00:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1039· OSTI ID:6573969

Marsden, P A; Hall, A V ^[1]; Heng, H Q; Duff, C L; Shi, X M; Tsui, L C ^[2]

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1. Univ. of Toronto (Canada)
2. Univ. of Toronto (Canada) Hospital for Sick Children, Toronto (Canada)

Nitric oxide (NO) is a simple molecule implicated in neuronal transmission, endothelium-dependent vasodilatation, and macrophage immunologic activation. Enzymes responsible for NO synthesis constitute a family with at least three distinct isoforms - neuronal (NOS1), endothelial (NOS3), and inducible tissue. NO synthase enzymatic activity is constitutively expressed but activation of the calcium/calmodulin signaling pathway is required for maximal activity. Constitutive NO synthases contrast with a pathway for NO synthesis evident in macrophages, Kupffer cells, hepatocytes, vascular smooth muscle, and mesangial cells, among others. NO synthase activity is induced in these cell types by cytokines or bacterial wall products over a period of many hours. 14 refs., 1 fig.

• OSTI ID: 6573969
• Journal Information: Genomics; (United States), Vol. 19:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 17
GENETIC MAPPING
LIGASES
GENES
NITRIC OXIDE
BIOSYNTHESIS
DNA HYBRIDIZATION
BIOTECHNOLOGY
CHALCOGENIDES
CHROMOSOMES
ENZYMES
GENETIC ENGINEERING
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
NITROGEN COMPOUNDS
NITROGEN OXIDES
NUCLEIC ACID HYBRIDIZATION
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PROTEINS
SYNTHESIS
550400* - Genetics