Biostimulation of wound healing in vivo by a helium-neon laser
Abstract
Clinical observations have suggested that low-energy lasers might stimulate wound healing. To understand the mechanism of the biostimulation, we previously examined the effects of low-energy lasers on collagen production by human skin fibroblasts and reported an increase of collagen synthesis in vitro. To examine the effects of low-energy lasers in vivo, hairless mice were experimentally wounded, sutured, and subjected to laser irradiation by a helium-neon laser with a power output of 1.56 mW and an energy fluence of 1.22 Joules/cm2. Experimental wounds were subjected to laser treatment every other day for 2 months; control wounds remained untreated. Specimens from the wounds were then examined for histological findings, tensile strength, and total collagen content. Results demonstrated a considerable improvement in the tensile strength of the laser-irradiated wounds at 1 and 2 weeks. Furthermore, the total collagen content was significantly increased at 2 months when compared with control wounds. These results suggest a beneficial effect of the helium-neon laser on wound healing in vivo.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of California, Los Angeles
- OSTI Identifier:
- 6570041
- Resource Type:
- Journal Article
- Journal Name:
- Ann. Plast. Surg.; (United States)
- Additional Journal Information:
- Journal Volume: 1
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; COLLAGEN; BIOSYNTHESIS; LASER RADIATION; BIOLOGICAL EFFECTS; WOUNDS; HEALING; BIOLOGICAL MODELS; HELIUM-NEON LASERS; IN VIVO; MICE; ANIMALS; BIOLOGICAL RECOVERY; ELECTROMAGNETIC RADIATION; GAS LASERS; INJURIES; LASERS; MAMMALS; ORGANIC COMPOUNDS; PROTEINS; RADIATIONS; RECOVERY; RODENTS; SCLEROPROTEINS; SYNTHESIS; VERTEBRATES; 560400* - Other Environmental Pollutant Effects
Citation Formats
Lyons, R F, Abergel, R P, White, R A, Dwyer, R M, Castel, J C, and Uitto, J. Biostimulation of wound healing in vivo by a helium-neon laser. United States: N. p., 1987.
Web. doi:10.1097/00000637-198701000-00011.
Lyons, R F, Abergel, R P, White, R A, Dwyer, R M, Castel, J C, & Uitto, J. Biostimulation of wound healing in vivo by a helium-neon laser. United States. https://doi.org/10.1097/00000637-198701000-00011
Lyons, R F, Abergel, R P, White, R A, Dwyer, R M, Castel, J C, and Uitto, J. 1987.
"Biostimulation of wound healing in vivo by a helium-neon laser". United States. https://doi.org/10.1097/00000637-198701000-00011.
@article{osti_6570041,
title = {Biostimulation of wound healing in vivo by a helium-neon laser},
author = {Lyons, R F and Abergel, R P and White, R A and Dwyer, R M and Castel, J C and Uitto, J},
abstractNote = {Clinical observations have suggested that low-energy lasers might stimulate wound healing. To understand the mechanism of the biostimulation, we previously examined the effects of low-energy lasers on collagen production by human skin fibroblasts and reported an increase of collagen synthesis in vitro. To examine the effects of low-energy lasers in vivo, hairless mice were experimentally wounded, sutured, and subjected to laser irradiation by a helium-neon laser with a power output of 1.56 mW and an energy fluence of 1.22 Joules/cm2. Experimental wounds were subjected to laser treatment every other day for 2 months; control wounds remained untreated. Specimens from the wounds were then examined for histological findings, tensile strength, and total collagen content. Results demonstrated a considerable improvement in the tensile strength of the laser-irradiated wounds at 1 and 2 weeks. Furthermore, the total collagen content was significantly increased at 2 months when compared with control wounds. These results suggest a beneficial effect of the helium-neon laser on wound healing in vivo.},
doi = {10.1097/00000637-198701000-00011},
url = {https://www.osti.gov/biblio/6570041},
journal = {Ann. Plast. Surg.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1987},
month = {Thu Jan 01 00:00:00 EST 1987}
}