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Title: Analysis of residual disease following preoperative radiotherapy versus initial surgery in endometrial carcinoma

Abstract

A clinicopathologic study of residual disease following pre-operative radiotherapy (RT) in 67 patients and initial surgery in 40 patients with early invasive endometrial carcinoma is presented. In 10%, extrauterine spread was found at operation. In 10% of patients, the histologic type, and in 19% the grade of tumor, differed between the curettage and hysterectomy specimens. Pre-op RT altered the depth of myometrial invasion and frequency of vascular invasion, but there was no evidence that irradiation itself affected the histologic type or grade of tumor. The patients with residual tumor after pre-op RT had significantly more cancer-related deaths than those without residual disease. The high risk factors were deep myometrial invasion and residual disease outside the uterus. Vascular invasion did not affect the prognosis in this series. The importance of surgical-pathologic staging by initial surgery is discussed.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Pennsylvania State Univ., Hershey, PA
OSTI Identifier:
6565965
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 8:2
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; RADIOTHERAPY; RADIATION DOSE DISTRIBUTIONS; EVALUATION; COBALT 60; EXTERNAL IRRADIATION; MEV RANGE 01-10; PATIENTS; SURGERY; UTERUS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COBALT ISOTOPES; DISEASES; ENERGY RANGE; FEMALE GENITALS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MEV RANGE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; THERAPY; YEARS LIVING RADIOISOTOPES; 550603* - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Chung, C K, Stryker, J A, Nahhas, W A, Cunningham, D E, and Mortel, R. Analysis of residual disease following preoperative radiotherapy versus initial surgery in endometrial carcinoma. United States: N. p., 1982. Web. doi:10.1016/0360-3016(82)90516-8.
Chung, C K, Stryker, J A, Nahhas, W A, Cunningham, D E, & Mortel, R. Analysis of residual disease following preoperative radiotherapy versus initial surgery in endometrial carcinoma. United States. https://doi.org/10.1016/0360-3016(82)90516-8
Chung, C K, Stryker, J A, Nahhas, W A, Cunningham, D E, and Mortel, R. 1982. "Analysis of residual disease following preoperative radiotherapy versus initial surgery in endometrial carcinoma". United States. https://doi.org/10.1016/0360-3016(82)90516-8.
@article{osti_6565965,
title = {Analysis of residual disease following preoperative radiotherapy versus initial surgery in endometrial carcinoma},
author = {Chung, C K and Stryker, J A and Nahhas, W A and Cunningham, D E and Mortel, R},
abstractNote = {A clinicopathologic study of residual disease following pre-operative radiotherapy (RT) in 67 patients and initial surgery in 40 patients with early invasive endometrial carcinoma is presented. In 10%, extrauterine spread was found at operation. In 10% of patients, the histologic type, and in 19% the grade of tumor, differed between the curettage and hysterectomy specimens. Pre-op RT altered the depth of myometrial invasion and frequency of vascular invasion, but there was no evidence that irradiation itself affected the histologic type or grade of tumor. The patients with residual tumor after pre-op RT had significantly more cancer-related deaths than those without residual disease. The high risk factors were deep myometrial invasion and residual disease outside the uterus. Vascular invasion did not affect the prognosis in this series. The importance of surgical-pathologic staging by initial surgery is discussed.},
doi = {10.1016/0360-3016(82)90516-8},
url = {https://www.osti.gov/biblio/6565965}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 8:2,
place = {United States},
year = {Mon Feb 01 00:00:00 EST 1982},
month = {Mon Feb 01 00:00:00 EST 1982}
}