Radiobiological basis of total body irradiation with different dose rate and fractionation: repair capacity of hemopoietic cells

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90195-4· OSTI ID:6564484

Song, C W; Kim, T H; Khan, F M; Kersey, J H; Levitt, S H

Total body irradiation (TBI) followed by bone marrow transplantation is being used in the treatment of malignant or non-malignant hemopoietic disorders. It has been believed that the ability of hemopoietic cells to repair sublethal radiation damage is negligible. Therefore, several schools of investigators suggested that TBI in a single exposure at extremely low dose rate (5 rad/min) over several hours, or in several fractions in 2-3 days, should yield a higher therapeutic gain, as compared with a single exposure at a high dose rate (25 rad/min). We reviewed the existing data in the literature, in particular, the response of hemopoietic cells to fractionated doses of irradiation and found that the repair capacity of both malignant and non-malignant hemopoietic cells might be greater than has been thought. It is concluded that we should not underestimate the ability of hemopoietic cells to repair sublethal radiation damage in using TBI.

• Research Organization: Univ. of Minnesota Medical School, Minneapolis
• OSTI ID: 6564484
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:12
• Country of Publication: United States
• Language: English

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BIOLOGICAL RADIATION EFFECTS
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NEOPLASMS
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