Cigarette smoke ventilation decreases prostaglandin inactivation in rat and hamster lungs

Journal Article · Tue Jun 01 00:00:00 EDT 1982 · Prostaglandins; (United States)

OSTI ID:6563146

Maennistoe, J; Uotila, P

The effects of cigarette smoke on the metabolism of exogenous PGE2 and PGF2 alpha were investigated in isolated rat and hamster lungs. When isolated lungs from animals were ventilated with cigarette smoke during pulmonary infusion of 100 nmol of PGE2 or PGF2 alpha, the amounts of the 15-keto-metabolites in the perfusion effluent were decreased. Pre-exposure of animals to cigarette smoke daily for 3 weeks did not change the metabolism of PGE2 when the lungs were ventilated with air. Cigarette smoke ventilation of lungs from pre-exposed animals caused, however, a similar decrease in the metabolism of PGE2 as in animals not previously exposed to smoke. After pulmonary injection of 10 nmol of /sup 14/C-PGE2 the radioactivity appeared more rapidly in the effluent during cigarette smoke ventilation suggesting inhibition of the PGE2 uptake mechanism. In rat lungs pulmonary vascular pressor responses to PGE2 and PGF2 alpha were inhibited by smoke ventilation.

• Research Organization: Department of Physiology, University of Turku, Finland
• OSTI ID: 6563146
• Journal Information: Prostaglandins; (United States), Vol. 23:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
PROSTAGLANDINS
METABOLISM
TOBACCO SMOKES
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
HAMSTERS
IN VITRO
INHIBITION
LUNGS
METABOLITES
PERFUSED ORGANS
RATS
RESPONSE MODIFYING FACTORS
UPTAKE
AEROSOLS
ANIMALS
BODY
COLLOIDS
DISPERSIONS
LABELLED COMPOUNDS
MAMMALS
ORGANS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques