Pathogenesis of lesions induced in rat lung by chronic tobacco smoke inhalation

Journal Article · Thu Jul 01 00:00:00 EDT 1982 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6559997

Heckman, C A; Dalbey, W E

Lesions were induced in the lungs of specific-pathogen-free F344 rats by chronic tobacco smoke exposure. Animals exposed to 7 cigarettes/day were killed after 1, 1.5 or 2 years of exposure. Parallel lifetime exposures induced pulmonary tumors in 9% of the animals. In serially killed animals, four types of lesions were found: (1) perivascular or peribronchiolar accumulation of lymphoreticular cells; (2) fibrotic and cellular enlargement of peribronchiolar septa; (3) type II cell hyperplasia with septal fibrosis; and (4) air-space enlargement (emphysema). However, emphysema occurred only in animals exposed to a higher (10 cigarettes) dose of tobacco smoke. Ultrastructural studies showed all of the focal lesions to be infiltrated by cells typical of the inflammatory response. The type II hyperplastic and peribronchiolar alveolar lesions involved larger portions of the parenchyma in fibrotic changes but differed in structure, location, and frequency. The incidence of the peribronchiolar alveolar lesions was temporally related to tumor incidence.

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6559997
• Journal Information: J. Natl. Cancer Inst.; (United States), Vol. 69:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
TOBACCO SMOKES
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
GERM-FREE ANIMALS
LUNGS
NEOPLASMS
PATHOGENESIS
PATHOLOGICAL CHANGES
RATS
RESPIRATORY SYSTEM DISEASES
AEROSOLS
ANIMALS
BODY
COLLOIDS
DATA
DISEASES
DISPERSIONS
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)