Assessment of demented patients by dynamic SPECT of inhaled xenon-133
We studied the potential for using dynamic single photon emission computed tomography of inhaled xenon-133 (/sup 133/Xe) gas in the assessment of demented patients. An advanced ring-type single photon emission computed tomography (SPECT) HEADTOME with improved spatial resolution (15 mm in full width at half maximum (FWHM)) was used for tomographic measurement of regional cerebral blood flow (rCBF). All 34 patients underwent a detailed psychiatric examination and x-ray computed tomography scan, and matched research criteria for Alzheimer's disease (n = 13), senile dementia of the Alzheimer type (n = 9), or multi-infarct dementia (n = 12). In comparison with a senile control group (n = 7), mean CBF of both the whole brain and the temporo-parietal region was significantly less in the Alzheimer's disease and senile dementia Alzheimer type groups, but no significant difference was seen between the senile control group and multi-infarct dementia group. The correlation was 0.72 (p less than 0.004) between the mean CBF of the whole brain and the score of Hasegawa's Dementia Scale, and 0.94 (p less than 0.0001) between rCBF of the temporo-parietal region and the scale in Alzheimer's disease. In the senile dementia Alzheimer type group, the correlations were 0.77 (p less than 0.01) and 0.83 (p less than 0.004) respectively. No significant correlations were found in the multi-infarct dementia group. A temporo-parietal reduction in the distribution of the rCBF characteristic in the Alzheimer's disease group and a patchy whole brain reduction characteristic in the multi-infarct dementia group was detected. The ability of our improved SPECT to provide both quantitative measurement of rCBF and characteristic rCBF distribution patterns, makes it a promising tool for research or routine examination of demented patients.
- Research Organization:
- Yamagata Univ. School of Medicine (Japan)
- OSTI ID:
- 6558258
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 29:10
- Country of Publication:
- United States
- Language:
- English
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PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
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ISOMERIC TRANSITION ISOTOPES
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NUCLEI
ORGANS
RADIOISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics