(75Se)Selenomethionine scanning for parathyroid localization should be abandoned

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Mayo Clin., Proc.; (United States)

DOI:https://doi.org/10.1016/S0025-6196(12)61491-8· OSTI ID:6551558

Waldorf, J C; van Heerden, J A; Gorman, C A; Grant, C S; Wahner, H W

Image subtraction techniques, in conjunction with (75Se)selenomethionine (75Se) scintigraphy, have recently been suggested to be a potentially valuable tool for localization of parathyroid abnormalities. With use of these techniques, we prospectively studied 15 patients scheduled for parathyroid operations. Postoperatively, all were normocalcemic. Anterior scintiscans of the neck were divided into quadrants, and regions of enhanced uptake were assigned to one or more quadrants. On this basis, by chance alone a minimum of 25% of single-gland enlargements would be assigned to the correct quadrant of the neck. We found that by use of 75Se scanning only 8 of 22 abnormal glands (36%) were assigned to the quadrant of the neck in which they were found intraoperatively. In no case was a clearly visualized focus of parathyroid activity encountered. These results do not justify the continued use of 75Se scintigraphy with or without image subtraction in the preoperative localization of parathyroid glands.

• Research Organization: Mayo Graduate School of Medicine, Rochester, Minnesota
• OSTI ID: 6551558
• Journal Information: Mayo Clin., Proc.; (United States), Vol. 59:8
• Country of Publication: United States
• Language: English

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