Astatine-211-tellurium radiocolloid cures experimental malignant ascites
Journal Article
·
· Science; (United States)
- Harvard Medical School, Boston, MA
An investigation of the efficacy of astatine-211-tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this ..cap alpha..-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with ..cap alpha..-emission. These results have important implications for the development and use of ..cap alpha..-emitters as radiocolloid therapy for the treatment of human tumors.
- DOE Contract Number:
- EY-76-S-4115; AC02-76CH0016
- OSTI ID:
- 6550586
- Journal Information:
- Science; (United States), Vol. 212:4492
- Country of Publication:
- United States
- Language:
- English
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Development and radiotherapeutic application of /sup 211/At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982
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Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
MICE
EHRLICH ASCITES TUMOR
RADIOCOLLOIDS
CELL KILLING
RADIOTHERAPY
ASTATINE 211
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
LABORATORY ANIMALS
LET
RBE
SURVIVAL CURVES
SURVIVAL TIME
TELLURIUM
ALPHA DECAY RADIOISOTOPES
ANIMALS
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
COLLOIDS
DATA
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENERGY TRANSFER
EXPERIMENTAL NEOPLASMS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INFORMATION
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOLOGY
RODENTS
SEMIMETALS
THERAPY
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
550603 - Medicine- External Radiation in Therapy- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
MICE
EHRLICH ASCITES TUMOR
RADIOCOLLOIDS
CELL KILLING
RADIOTHERAPY
ASTATINE 211
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
LABORATORY ANIMALS
LET
RBE
SURVIVAL CURVES
SURVIVAL TIME
TELLURIUM
ALPHA DECAY RADIOISOTOPES
ANIMALS
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
COLLOIDS
DATA
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENERGY TRANSFER
EXPERIMENTAL NEOPLASMS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INFORMATION
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOLOGY
RODENTS
SEMIMETALS
THERAPY
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
550603 - Medicine- External Radiation in Therapy- (1980-)