Hydroxylation of biphenyl by Aspergillus toxicarius: conditions for a bench scale fermentation process

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Biotechnol. Bioeng.; (United States)

DOI:https://doi.org/10.1002/bit.260260506· OSTI ID:6548484

Golbeck, J H; Cox, J C

Fungi of the Aspergillus sp. can hydroxylate biphenyl to 4,4'-dihydroxybiphenyl, a chemical intermediate used in the plastics industry. The authors studied various batch culture conditions for the production of 4,4'-dihydroxybiphenyl, by Aspergillus toxicarius, in 25-mL shake flasks and 2-L fermenter cultures. Conditions investigated included temperature, aeration, carbon and nitrogen sources, biomass content, and time of substrate addition. Under optimum conditions the authors observed a rate of 4,4'-dihydroxybiphenyl production of 15-20 mg/day/g dry wt mycelia. Such a production rate is probably too low to support a commercial process and possible reasons for the low productivity are discussed.

• Research Organization: Martin Marietta Laboratories, Baltimore, MD
• OSTI ID: 6548484
• Journal Information: Biotechnol. Bioeng.; (United States), Vol. 26:5
• Country of Publication: United States
• Language: English

Related Subjects

09 BIOMASS FUELS
ASPERGILLUS
BATCH CULTURE
PLANT GROWTH
BIPHENYL
HYDROXYLATION
BENCH-SCALE EXPERIMENTS
FERMENTATION
AROMATICS
BIOCONVERSION
FUNGI
GROWTH
HYDROCARBONS
ORGANIC COMPOUNDS
PLANTS
090222* - Alcohol Fuels- Preparation from Wastes or Biomass- (1976-1989)