Environmental exposure to N-aryl compounds
N-aryl compounds are well-known occupational exposure hazards but are relatively unstudied as an environmental exposure problem. Coal-derived liquid fuels and environmental tobacco smoke are examples of materials potentially leading to significant environmental exposures to aryl amines. Integrated chemical class separation and bacterial mutagenicity testing identified primary aromatic amines as the major contributors to the mutagenicities of crude coal liquids. Studies of sidestream cigarette smoke chemistry show that alkaline constituents of cigarette smoke are preferentially released into the environment as compared to that drawn into the mouth by the smoker. Two to ten times the quantity of aromatic amines are released in the sidestream smoke on a per cigarette basis. Quantities of the more mutagenic and carcinogenic multi-ring aryl amines in both coal liquids and in cigarette smoke are very small and they are accompanied by a wide variety of related compounds. Chemical ionization mass spectrometric methods have been developed to distinguish between closely related amines to facilitate their identification and quantitation at trace levels.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6544427
- Report Number(s):
- CONF-8704125-1; ON: DE87010392
- Resource Relation:
- Conference: 3. international conference on carcinogenic and mutagenic N-substituted aryl compounds, Dearborn, MI, USA, 25 Apr 1987; Other Information: Paper copy only, copy does not permit microfiche production
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
POLYCYCLIC AROMATIC AMINES
ENVIRONMENTAL EFFECTS
POLYCYCLIC NITRO COMPOUNDS
COAL LIQUIDS
PYRIDINE
TOBACCO SMOKES
AEROSOLS
AMINES
AZINES
COLLOIDS
DISPERSIONS
FLUIDS
HETEROCYCLIC COMPOUNDS
LIQUIDS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
RESIDUES
SMOKES
SOLS
560300* - Chemicals Metabolism & Toxicology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)