Quantification of infarct size by /sup 201/Tl single-photon emission computed tomography during acute myocardial infarction in humans. Comparison with enzymatic estimates

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.78.4.831· OSTI ID:6544092

Mahmarian, J J; Pratt, C M; Borges-Neto, S; Cashion, W R; Roberts, R; Verani, M S

We prospectively investigated whether /sup 201/Tl single-photon emission computed tomography (SPECT) could accurately diagnose the presence and quantify the extent of acute myocardial infarction when compared with infarct size assessed by plasma MB-creatine kinase activity. Thirty patients with enzymatic evidence of infarction were imaged within 12-36 hours of chest pain (mean, 23.4 hours). No patient had a previous infarction, and none underwent intervention seeking to restore coronary patency. Infarct size was quantified with computer-generated polar maps of the myocardial radioactivity and expressed as a percentage of the total left ventricular volume. To assess left and right ventricular performance, blood-pool gated radionuclide angiography was performed immediately after SPECT. All 30 patients had perfusion defects consistent with myocardial infarction. Scintigraphic and enzymatic estimates of infarct size correlated well for the group as a whole (r = 0.78, p less than 0.001, SEE = 9.1) but especially for those patients with anterior infarction (r = 0.91, p less than 0.001, SEE = 7.9). The poor correlation observed in patients with inferior infarction (r = 0.50, p less than 0.05, SEE = 10.0) was believed to be related to the frequent occurrence of right ventricular involvement because SPECT assessed only left ventricular damage, whereas the enzymatic method estimated the myocardial injury in both ventricles. A quantitative index of right ventricular infarct size, derived from the relation between the scintigraphic and enzymatic estimates, had a strong inverse correlation with right ventricular ejection fraction (r = -0.89, p less than 0.001, SEE = 3.6).

• Research Organization: Baylor College of Medicine, Houston, TX (USA)
• OSTI ID: 6544092
• Journal Information: Circulation; (United States), Vol. 78:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
MYOCARDIAL INFARCTION
DIAGNOSIS
PHOSPHOTRANSFERASES
ENZYME ACTIVITY
COMPARATIVE EVALUATIONS
PATIENTS
PERFUSED ORGANS
THALLIUM 201
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENZYMES
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
TOMOGRAPHY
TRANSFERASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics