The effects of ionizing radiation and dexamethasone on the blood-brain-barrier (BBB) and blood-tumor-barrier (BTB): Implications for boron neutron capture therapy (BNCT) of brain tumors

Conference · Fri Jan 01 00:00:00 EST 1988

OSTI ID:6540749

Dorn, III, R V; Spickard, J H; Griebenow, M L

Currently envisioned techniques for Boron Neutron Capture Therapy (BNCT) of brain tumors rely on the increased permeability of the blood-brain-barrier (BBB) (more specifically, the blood-tumor-barrier (BTB)) which occurs around the malignant tumor. As a result of this increased permeability, higher boron concentrations (Na/sub 2/B/sub 12/H/sub 11/SH) should be obtainable in the tumor than in the surrounding normal brain. The effects on the BBB and BTB by the ionizing component of this radiation and by the steroid dexamethasone (almost universally used in the clinical management of these patients) must be considered in the formulation of this treatment technique. 32 refs., 5 tabs.

• Research Organization: EG and G Idaho, Inc., Idaho Falls (USA)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 6540749
• Report Number(s): EGG-M-88039; CONF-8805150-2; ON: DE89005175
• Resource Relation: Conference: 4. international conference on neutron capture therapy, Bremen, F.R. Germany, 31 May 1988; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD-BRAIN BARRIER
PERMEABILITY
DEXAMETHASONE
BIOLOGICAL EFFECTS
IONIZING RADIATIONS
BORON COMPOUNDS
BRAIN
CATS
DOGS
DOSE-RESPONSE RELATIONSHIPS
HUMAN POPULATIONS
NEOPLASMS
NEUTRON CAPTURE THERAPY
RATS
ADRENAL HORMONES
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
CORTICOSTEROIDS
DISEASES
GLUCOCORTICOIDS
HYDROXY COMPOUNDS
KETONES
MAMMALS
MEDICINE
NERVOUS SYSTEM
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
POPULATIONS
PREGNANES
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
STEROIDS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560151 - Radiation Effects on Animals- Man