Assessment of dopamine receptor densities in the human brain with carbon-11-labeled N-methylspiperone

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410150715· OSTI ID:6539378

Wagner, Jr, H N; Burns, H D; Dannals, R F; Wong, D F; Langstroem, B; Duelfer, T; Frost, J J; Ravert, H T; Links, J M; Rosenbloom, S B

We describe the use of carbon-11-labeled 3-N-methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

• Research Organization: Division of Nuclear Medicine, Johns Hopkins Medical Institution, Baltimore, MD
• OSTI ID: 6539378
• Journal Information: Ann. Neurol.; (United States), Vol. 15 Suppl
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
TOMOGRAPHY
DOPAMINE
RECEPTORS
CARBON 11
CHEMICAL BONDS
LABELLED COMPOUNDS
MAN
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DRUGS
EVEN-ODD NUCLEI
HYDROXY COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PRIMATES
RADIOISOTOPES
SYMPATHOMIMETICS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics