Comparison of skull and femur lead levels in adult rats

Journal Article · Mon Dec 01 00:00:00 EST 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90060-2· OSTI ID:6538169

Denton, J E; Potter, G D; Santolucito, J A

The purpose of the study was to elucidate the relationship between skull and femur lead levels in laboratory rats. Forty-eight female rats were given one of four lead chloride drinking water solutions: 0.05, 0.58, 17, or 352 ppM lead. Two animals from each group were sacrificed after 3, 6, 9, 12, 15, and 24 weeks of treatment. Both femurs and the frontal and parietal bones of the skull were removed from each animal and analyzed for lead concentration by atomic absorption spectroscopy. A significant accumulation of lead was observed in femurs and skull bones only from animals in the 352 ppM lead treatment group. The lead concentrations of the femurs were significantly higher than skull lead concentrations for all groups and this relationship was described using a linear regression equation.

• Research Organization: Environmental Protection Agency, Las Vegas, NV
• OSTI ID: 6538169
• Journal Information: Environ. Res.; (United States), Vol. 23:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FEMUR
SENSITIVITY
LEAD
METABOLISM
SKULL
ABSORPTION SPECTROSCOPY
BIOLOGICAL LOCALIZATION
BUILDUP
COMPARATIVE EVALUATIONS
DRINKING WATER
EQUATIONS
QUANTITY RATIO
RATS
TIME DEPENDENCE
ANIMALS
BODY
ELEMENTS
HYDROGEN COMPOUNDS
MAMMALS
METALS
ORGANS
OXYGEN COMPOUNDS
RODENTS
SKELETON
SPECTROSCOPY
VERTEBRATES
WATER
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)