Mechanistic explanations for the elevated susceptibility of the perinatal thyroid gland to radiogenic cancer

Conference · Tue Dec 06 00:00:00 EST 1988

OSTI ID:6537271

Sikov, M R; Mahlum, D D; Dagle, G E; Daniel, J L; Goldman, M

Results from laboratory experiments and epidemiologic studies suggest that the thyroid gland is more susceptible to radiogenic cancer during the late prenatal or early postnatal periods than in adulthood. We have evaluated several endpoints in the course of experiments in which rats, at ages ranging from late gestation to adulthood, were exposed to graded doses of /sup 131/I. Morphologic responses at sequential times after exposure were evaluated in one series of experiments. Cell death, degeneration, fibrosis of the gland were the predominant findings after exposure of weanlings or adults, but inhibition of thyroid growth and differentiation was the characteristic change after perinatal exposure. The degree of maturation and dosimetric factors are involved in this differential morphologic response, and also result in age-dependent physiologic differences in the postexposure period.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6537271
• Report Number(s): PNL-SA-16158; CONF-8810209-11; ON: DE89006943
• Resource Relation: Conference: 27. Hanford life sciences symposium on health and the environment, Richland, WA, USA, 18 Oct 1988; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
IODINE 131
BIOLOGICAL EFFECTS
NEOPLASMS
RADIOINDUCTION
ANIMAL CELLS
DOSIMETRY
FETUSES
GROWTH
PRENATAL IRRADIATION
RATS
RESPONSE MODIFYING FACTORS
RISK ASSESSMENT
THYROID
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOGENESIS
PRENATAL EXPOSURE
RADIOISOTOPES
RODENTS
VERTEBRATES
560151* - Radiation Effects on Animals- Man