Effects of lithium chloride on testicular steroidogenic and gametogenic functions in mature male albino rats
- Calcutta Univ. (India)
The present study was undertaken to evaluate the effects of lithium, on steroidogenic and gametogenic functions of testis in the rat. Adult male rats of Wistar strain were injected with lithium chloride at the dose of 0.1 mg, 0.2 mg, and 0.4 mg/100 g body weight/day for 21 days. All the treated animals along with the vehicle treated controls were sacrificed 24 hours after the last injections. Testicular steroidogenic activity was evaluated by measuring the activities of two steroidogenic key enzymes, {Delta}{sup 5}-3{beta} hydroxysteriod dehydrogenase ({Delta}{sup 5} -3{beta}-HSD) and 17{beta} hydroxysteroid dehydrogenase (17{beta} -HSD). Gametogenic capacity was determined by counting the number of germ cells at stage VII of seminiferous cycle. Plasma levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and testosterone (T) were measured by radioimmunoassay (RIA). Administration of lithium chloride at a dose of 0.1 mg/100g body wt. for 21 days led to insignificant changes of plasma FSH, LH, PRL and T along with unaltered activities of testicular {Delta}5 -3{beta}-HSD, 17 {beta}-HSD activities and gametogenesis.
- OSTI ID:
- 6532922
- Journal Information:
- Life Sciences; (USA), Vol. 46:2; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LITHIUM CHLORIDES
BIOLOGICAL EFFECTS
OXIDOREDUCTASES
ENZYME ACTIVITY
TESTES
BIOLOGICAL FUNCTIONS
FSH
LH
LTH
MALES
RADIOIMMUNOASSAY
RATS
TESTOSTERONE
ALKALI METAL COMPOUNDS
ANDROGENS
ANDROSTANES
ANIMALS
BIOASSAY
BODY
CHLORIDES
CHLORINE COMPOUNDS
DIAGNOSTIC TECHNIQUES
ENZYMES
FUNCTIONS
GONADOTROPINS
GONADS
HALIDES
HALOGEN COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KETONES
LITHIUM COMPOUNDS
LITHIUM HALIDES
MALE GENITALS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RODENTS
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques