Action of a new cholinergic agonist, aclatonium napadisilate, on isolated rat pancreatic acini

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Pancreas; (USA)

DOI:https://doi.org/10.1097/00006676-199007000-00009· OSTI ID:6532041

Fujii, M; Okabayashi, Y; Nakamura, T; Tani, S; Fujisawa, T; Otsuki, M ^[1]

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1. Kobe Univ. School of Medicine (Japan)

The effect of aclatonium napadisilate, a newly synthesized choline ester, on pancreatic exocrine function was compared with that of the muscarinic agonist carbamylcholine in isolated rat pancreatic acini. Both compounds increased amylase release and {sup 45}Ca{sup 2+} efflux in a dose-dependent fashion, and similarly decreased the binding of (N-methyl-{sup 3}H)scopolamine to isolated rat pancreatic acini. While aclatonium napadisilate was 20-30 times less potent than carbamylcholine in stimulations of amylase release and {sup 45}Ca{sup 2+} efflux, the potency of aclatonium napadisilate in inhibiting (N-methyl-{sup 3}H)scopolamine binding was nearly the same as that of carbamylcholine. These results indicate that aclatonium napadisilate stimulates pancreatic exocrine secretion via muscarinic receptors and Ca{sup 2+} mobilization, and its intrinsic activity is less than carbamylcholine in the isolated rat pancreatic acini. Since aclatonium napadisilate is known to increase motility and peristalsis of the gastrointestinal tract, stimulatory effects of aclatonium napadisilate, shown in the present study, on digestive enzyme secretion from the pancreas may provide additional benefit of aclatonium napadisilate in the treatment of various gastrointestinal disorders.

• OSTI ID: 6532041
• Journal Information: Pancreas; (USA), Vol. 5:4; ISSN 0885-3177
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CALCIUM COMPOUNDS
MEMBRANE TRANSPORT
PANCREAS
BIOLOGICAL FUNCTIONS
PARASYMPATHOMIMETICS
BIOCHEMICAL REACTION KINETICS
AMYLASE
CALCIUM 45
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM DISEASES
DOSE-RESPONSE RELATIONSHIPS
RATS
TRACER TECHNIQUES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ENDOCRINE GLANDS
ENZYMES
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
GLYCOSYL HYDROLASES
HYDROLASES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
NUCLEI
O-GLYCOSYL HYDROLASES
ORGANS
RADIOISOTOPES
REACTION KINETICS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques