Importance of transcapillary insulin transport on insulin action in vivo

Miscellaneous · Sun Jan 01 00:00:00 EST 1989

OSTI ID:6531735

Yang, Y J

The relationship between transcapillary insulin transport and insulin action was examined in normal conscious dogs. Plasma and thoracic duct lymph insulin, and insulin action were simultaneously measured during euglycemic clamps and intravenous glucose tolerance tests. During the clamps, while {sup 14}C-inulin reached an equilibrium, steady-state (ss) plasma insulin was higher than lymph and the ratio of 3:2 was maintained during basal, activation and deactivation phases: 18 {+-} 2 vs. 12 {+-} 1, 51 {+-} 2 vs. 32 {+-} 1, and 18 {+-} 3 vs. 13 {+-} 1 {mu}U/ml. In addition, it took longer for lymph insulin to reach ss than plasma insulin during activation and deactivation: 11 {+-} 2 vs. 31 {+-} 5 and 8 {+-} 2 vs. 32 {+-} 6 min. During IVGTT, plasma insulin peaked within 5 {+-} 2 min; lymph insulin rose slowly to a lower peak. The significant gradient and delay between plasma and lymph insulin concentrations suggest a restricted transcapillary insulin transport.

• Research Organization: University of Southern California, Los Angeles, CA (USA)
• OSTI ID: 6531735
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
METABOLISM
INSULIN
MEMBRANE TRANSPORT
BIOCHEMICAL REACTION KINETICS
CARBON 14 COMPOUNDS
DOGS
IN VIVO
INULIN
TRACER TECHNIQUES
ALDEHYDES
ANIMALS
CARBOHYDRATES
HEXOSES
HORMONES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
POLYSACCHARIDES
REACTION KINETICS
SACCHARIDES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques