Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene

Journal Article · Tue Mar 01 00:00:00 EST 1988 · Journal of Virology; (USA)

OSTI ID:6530816

Ghazal, P; Lubon, H; Hennighausen, L ^[1]

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1. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (USA)

Repeat sequence motifs as well as unique sequences between nucleotides {minus}150 and {minus}22 of the human cytomegalovirus immediate-early 1 gene interact in vitro with nuclear proteins. The authors show that a transcriptional element between nucleotides {minus}91 and {minus}65 stimulated promoter activity in vivo and in vitro by binding specific cellular transcription factors. Finally, a common sequence motif, (T)TGG/AC, present in 15 of the determined binding sites suggests a particular class of nuclear factors associated with the immediate-early 1 gene.

• OSTI ID: 6530816
• Journal Information: Journal of Virology; (USA), Vol. 62:3; ISSN 0022-538X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENE OPERONS
BIOCHEMICAL REACTION KINETICS
TRANSCRIPTION FACTORS
VIRUSES
DNA SEQUENCING
GENE REGULATION
HELA CELLS
KINETICS
MICROORGANISMS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PARASITES
PROTEINS
REACTION KINETICS
STRUCTURAL CHEMICAL ANALYSIS
550201* - Biochemistry- Tracer Techniques