Altered erythrocyte Na/sup +/ + K/sup +/ pump in adolescent obesity

Journal Article · Mon Nov 01 00:00:00 EST 1982 · Metabolism; (United States)

OSTI ID:6530738

DeLuise, M; Rappaport, E; Flier, J S

The number of Na/K pump units and the cation transport activity of the pump were measured in erythrocytes from two etiologically different groups of obese adolescents and a group of normal controls. There was a significant reduction in the number of pump units, as measured by saturation ouabain binding, in erythrocytes from adolescents with idiopathic, early onset obesity. Individuals whose obesity developed subsequent to the appearance of a variety of hypothalamic lesions showed no reduction in the red cell complement of Na/K pump when compared to controls and the cation transport activity of their cells was higher than both the controls and the subjects with idiopathic obesity. These results support data obtained in adults that reduced red cell Na/K pump levels are seen in a group of individuals with idiopathic obesity. They further suggest that such reductions are not likely to be secondary to the obese state per se.

• Research Organization: Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA
• OSTI ID: 6530738
• Journal Information: Metabolism; (United States), Vol. 31:11
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
METABOLIC DISEASES
PATHOLOGY
POTASSIUM
MEMBRANE TRANSPORT
SODIUM
ADOLESCENTS
BIOCHEMISTRY
ERYTHROCYTES
PATIENTS
AGE GROUPS
ALKALI METALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMISTRY
DISEASES
ELEMENTS
MATERIALS
METALS
550900* - Pathology
550200 - Biochemistry
550300 - Cytology