Increased incorporation of /sup 14/C-palmitate into tissue lipids by isolated heart myocytes in endotoxic shock
Abstract
The incorporation of /sup 14/C-palmitate into various classes of tissue lipids by isolated adult dog heart myocytes was studied in an attempt to understand the pathophysiology of myocardial dysfunction during endotoxic shock. The results showed that the incorporation of /sup 14/C-palmitate into phospholipids was increased by 85.3% and 108.8% at 0.5 hours and two hours, respectively, following endotoxin (0.5 mg Escherichia coli lipopolysaccharide B per kg body weight) administration. Incorporation of radioactive palmitate into triglycerides was increased by 50.9% and 107.2% at 0.5 and two hours, respectively, postendotoxin. Incorporation of /sup 14/C-palmitate into diglycerides was stimulated by 51.9% and 64.5% at 0.5 and two hours, respectively, after endotoxin injection. The incorporation of /sup 14/C-palmitate into tissue-free fatty acids and unaltered at 0.5 hours but it was increased by 211.7% at two hours postendotoxin. These data demonstrated that myocardial membrane lipid profile was greatly altered by increased incorporation of /sup 14/C-palmitate into phospholipids and neutral lipids after endotoxin administration. An alteration in myocardial lipid profile, as reported in this study, may contribute to the development of myocardial dysfunction during shock.
- Authors:
- Publication Date:
- OSTI Identifier:
- 6530690
- Resource Type:
- Journal Article
- Journal Name:
- Adv. Shock Res.; (United States)
- Additional Journal Information:
- Journal Volume: 7
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; CARBON 14 COMPOUNDS; TRACER TECHNIQUES; CARDIOVASCULAR DISEASES; PATHOLOGY; BIOLOGICAL SHOCK; DOGS; ENDOTOXINS; HEART; HEXADECANOIC ACID; LIPIDS; PHYSIOLOGY; ANIMALS; ANTIGENS; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR SYSTEM; DISEASES; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; TOXIC MATERIALS; TOXINS; VERTEBRATES; 550901* - Pathology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques
Citation Formats
Liu, M S. Increased incorporation of /sup 14/C-palmitate into tissue lipids by isolated heart myocytes in endotoxic shock. United States: N. p., 1982.
Web.
Liu, M S. Increased incorporation of /sup 14/C-palmitate into tissue lipids by isolated heart myocytes in endotoxic shock. United States.
Liu, M S. 1982.
"Increased incorporation of /sup 14/C-palmitate into tissue lipids by isolated heart myocytes in endotoxic shock". United States.
@article{osti_6530690,
title = {Increased incorporation of /sup 14/C-palmitate into tissue lipids by isolated heart myocytes in endotoxic shock},
author = {Liu, M S},
abstractNote = {The incorporation of /sup 14/C-palmitate into various classes of tissue lipids by isolated adult dog heart myocytes was studied in an attempt to understand the pathophysiology of myocardial dysfunction during endotoxic shock. The results showed that the incorporation of /sup 14/C-palmitate into phospholipids was increased by 85.3% and 108.8% at 0.5 hours and two hours, respectively, following endotoxin (0.5 mg Escherichia coli lipopolysaccharide B per kg body weight) administration. Incorporation of radioactive palmitate into triglycerides was increased by 50.9% and 107.2% at 0.5 and two hours, respectively, postendotoxin. Incorporation of /sup 14/C-palmitate into diglycerides was stimulated by 51.9% and 64.5% at 0.5 and two hours, respectively, after endotoxin injection. The incorporation of /sup 14/C-palmitate into tissue-free fatty acids and unaltered at 0.5 hours but it was increased by 211.7% at two hours postendotoxin. These data demonstrated that myocardial membrane lipid profile was greatly altered by increased incorporation of /sup 14/C-palmitate into phospholipids and neutral lipids after endotoxin administration. An alteration in myocardial lipid profile, as reported in this study, may contribute to the development of myocardial dysfunction during shock.},
doi = {},
url = {https://www.osti.gov/biblio/6530690},
journal = {Adv. Shock Res.; (United States)},
number = ,
volume = 7,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1982},
month = {Fri Jan 01 00:00:00 EST 1982}
}