Post operative radiation therapy in the management of brain astrocytomata: retrospective study of 142 patients
A retrospective analysis of survival data of 142 patients with partially resected astrocytoma Grades II, III, and IV is presented. All patients received post-operative radiation therapy in the period 1957 to 1978 inclusive. There were 27 patients with Grade II tumors was 44%, and for Grade III 26%. The on, two, and three year survival rates for Grade II, 41 patients with Grade III, and 74 with Grade IV tumors. Two patients received a dose of 3800 and 4000 rad respectively, 86 a dose of 4000 to 5000 rad, and 54 a dose of 5000 to 6500 rad. The actuarial 5 year survival for patients with Grade II tumors was 44% and for Grade III 26%. The one, two, and three year survival rates for Grade IV were 33%, 15%, and 6.9% repectively. Median survival values were calculated according to histologic grade of malignancy for the whole group and for dead and alive patients separately. Of 27 patients with Grade II tumors, 11 patients were alive with a median survival of 63.7 months; 10 of 41 Grade III patients were alive with a median survival of 54 months; 7 of 74 Grade IV patients were alive with a median survival of 13.2 mon ths. There was no apparent dose effect on the median survival for Grade II and III patients. Patients with Grade IV tumors had a median survival of 12.1 months if they received doses between 4000 to 5000 rad and 14 months if they received doses between 5000 to 6500 rad. In view of the favorable 5 year survival rates of patients with Grade II and III astrocytoma, a dose of 5000 rad given as outlined in the text is both adequate and safe.
- Research Organization:
- Univ. of Nijmegen, Netherlands
- OSTI ID:
- 6528132
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:2
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
RADIOTHERAPY
PATIENTS
QUALITY OF LIFE
SURVIVAL TIME
SURVIVAL CURVES
BRAIN
DATA COMPILATION
EXPERIMENTAL DATA
NERVOUS SYSTEM DISEASES
RADIATION DOSES
SURGERY
X RADIATION
BODY
CENTRAL NERVOUS SYSTEM
DATA
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
INFORMATION
IONIZING RADIATIONS
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
RADIATIONS
RADIOLOGY
THERAPY
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550603 - Medicine- External Radiation in Therapy- (1980-)