Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Metabolism, Clinical and Experimental; (USA)

DOI:https://doi.org/10.1016/0026-0495(90)90131-U· OSTI ID:6527349

Jandacek, R J; Ramirez, M M; Crouse, III, J R ^[1]

---

1. Procter Gamble Company, Cincinnati, OH (USA)

Olestra, a nonabsorbable fat substitute comprising long-chain fatty acid esters of sucrose, had been previously shown to reduce cholesterol absorption in humans when ingested at a level of 50 g/d. To determine whether or not a lower level of dietary olestra would also reduce cholesterol absorption, we studied the effect of 7 g of olestra twice a day in 20 normocholesterolemic male inpatients in a double-blind, crossover trial. Two 6-day diet treatment and stool collection periods were separated by a 14-day washout period. Half of the subjects received butter, and half, a butter-olestra blend during each treatment period according to a crossover design. All subjects ingested trace amounts of 3H-cholesterol and 14C-beta-sitosterol with the butter or the butter-olestra blend. Cholesterol absorption was determined from the 3H/14C ratios in the diet and in saponified and extracted stools according to previously validated methodology. Cholesterol absorption during the butter regimen was significantly greater than that during the olestra regimen (56.1% +/- 1.6% v 46.7% +/- 1.1%, P less than .01).

• OSTI ID: 6527349
• Journal Information: Metabolism, Clinical and Experimental; (USA), Vol. 39:8; ISSN 0026-0495
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHOLESTEROL
INTESTINAL ABSORPTION
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DIET
ISOTOPE DILUTION
ISOTOPE RATIO
MAN
METABOLISM
SACCHAROSE
TRITIUM COMPOUNDS
ABSORPTION
ANIMALS
CARBOHYDRATES
DISACCHARIDES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
OLIGOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
SACCHARIDES
STEROIDS
STEROLS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
550501* - Metabolism- Tracer Techniques