First-generation litter-size reduction following irradiation of spermatogonial stem cells in mice and its use in risk estimation
Litter-size reduction (LSR) is a useful measure of part of the overall F/sub 1/ radiation-induced damage. Extensive LSR data were obtained as a by-product of specific-locus experiments. Fourteen such experiments involving 158,490 F/sub 1/ litters have been analyzed for the extent of LSR induced by x- or gamma-irradiation of spermatogonia. Litter sizes were compared between experimental and control groups at about 3 weeks after birth. At the high dose rate of 90 R/min, the LSRs showed a humped dose-response curve. There was a pronounced dose-rate effect, the mutational responses being much less at dose rates of 0.009 R/min and 0.001 R/min. It is estimated that if men were exposed to 1 R of radiation delivered at low linear energy transfer (low LET) and low dose rate, the number of deaths caused by induced dominant mutations among their children before late childhood would be about 19 per million live-born. This can be added to the earlier estimate of an approximately equal number of viable disorders in all body systems as based on dominant skeletal mutations. This gives a total estimate of induced dominant damage, but much of this addition represents death in very early embryonic life that would not be recognized in humans. The LSR data also permit the conclusion that only an extremely small proportion of serious radiation-induced genetic disorders among live-born humans would be expected to result from segmental aneuploidy.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6526239
- Journal Information:
- Environ. Mutagen.; (United States), Vol. 7:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DOMINANT MUTATIONS
RISK ASSESSMENT
SPERMATOGONIA
GENETIC RADIATION EFFECTS
CESIUM 137
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
LITTER SIZE
MICE
STEM CELLS
X RADIATION
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CESIUM ISOTOPES
ELECTROMAGNETIC RADIATION
GAMETES
GENETIC EFFECTS
GERM CELLS
IONIZING RADIATIONS
ISOTOPES
MAMMALS
MUTATIONS
NUCLEI
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals