Development of brachytherapy technique for nasal tumors in dogs

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · American Journal of Veterinary Research; (USA)

OSTI ID:6526183

White, R; Walker, M; Legendre, A M; Hoopes, J; Smith, J; Horton, S B ^[1]

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1. Univ. of Tennessee, Knoxville (USA)

Two groups of 4 dogs underwent nasal and ethmoidal turbinectomies followed by irradiation (mean minimal) doses of 5,390 and 6,550 cGy of radiation, respectively from implanted intracavitary sources of iridium 192. Two dogs from each group were euthanatized for histologic evaluation at 3 months after irradiation. The remaining 2 dogs from each group were euthanatized for similar evaluation at 6 months after irradiation. During the course of the study, few clinical complications were encountered. Histologic evaluation of the tissues forming the nasal passages revealed loss of epithelial lining and fibrous tissue replacement of surrounding bone. A direct correlation of pathologic changes could not be associated with the amount of radiation received, but there seemed to be a tendency for greater change in those dogs given higher doses and those kept alive for 6 months.

• OSTI ID: 6526183
• Journal Information: American Journal of Veterinary Research; (USA), Vol. 51:8; ISSN 0002-9645
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
EXPERIMENTAL NEOPLASMS
RADIOTHERAPY
NOSE
DOGS
EPITHELIUM
FIBROSIS
IRIDIUM 192
RADIATION DOSES
RADIATION SOURCE IMPLANTS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BODY AREAS
DAYS LIVING RADIOISOTOPES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
FACE
HEAD
HEAVY NUCLEI
IMPLANTS
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
PATHOLOGICAL CHANGES
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
TISSUES
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)