Low-dose total body irradiation in non-Hodgkin lymphoma: Short- and long-term toxicity and prognostic factor

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · American Journal of Clinical Oncology; (USA)

DOI:https://doi.org/10.1097/00000421-199008000-00002· OSTI ID:6526126

De Neve, W J; Lybeert, M L; Meerwaldt, J H ^[1]

---

1. A.Z.-V.U.B., Brussels (Belgium)

The toxicity of low-dose total body irradiation (LTBI), the prognostic factors related to survival and relapse-free survival, and the efficacy of treatment given for relapse after LTBI were analyzed in 68 patients with non-Hodgkin lymphoma (NHL) treated at the Rotterdamsch Radiotherapeutisch Instituut. All patients received LTBI between 1973 and 1979. The patient material was heterogeneous with respect to malignancy grade, stage, age, and therapy given before or after LTBI; the unifying principle was that all patients received LTBI and had symptomatic NHL. Analysis of prognostic variables with Cox's model revealed grade (p less than 0.001) and age (p = 0.004) as predictors for survival and grade (p less than 0.001) and dose of LTBI (p = 0.056) as predictors for relapse-free survival after LTBI. No subjective toxicity was observed during or after LTBI treatment. Hematologic toxicity was dose-limiting and was increased if patients had received cytotoxic treatment before LTBI. LTBI-related hematologic toxicity was lower in patients with low-grade NHL than in those with intermediate or high-grade NHL, was limited in time, and recovered in all patients. Patients relapsing after LTBI received a variety of therapies. Response rates were high, but of short duration, especially in intermediate or high-grade NHL. Duration of response was progressively shorter after multiple relapses.

• OSTI ID: 6526126
• Journal Information: American Journal of Clinical Oncology; (USA), Vol. 13:4; ISSN 0277-3732
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LYMPHOMAS
RADIOTHERAPY
LOW DOSE IRRADIATION
MATHEMATICAL MODELS
MULTIVARIATE ANALYSIS
PATIENTS
SURVIVAL CURVES
TOXICITY
WHOLE-BODY IRRADIATION
DISEASES
EXTERNAL IRRADIATION
IMMUNE SYSTEM DISEASES
IRRADIATION
MATHEMATICS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIOLOGY
STATISTICS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)