Fractionated sublethal total body irradiation and donor bone marrow infusion for induction of specific allograft tolerance
Fractionated total lymphoid irradiation (FT-lymphoid-I) plus donor bone marrow (BM) can induce tolerance to skin allografts. In the present study, fractionated total body irradiation (FT-body-I) was studied as an alternative to FT-lymphoid-I. FT-body-I produces less pulmonary and gastrointestinal injury than does single exposure total body irradiation, but because of the decreased capacity of lymphoid tissues to recover from the effects of irradiation between fractions, the effect of FT-body-I on lymphoid cells, when delivered within 24 h, is approximately the same as an equivalent single exposure of total body irradiation. Therefore, FT-body-I, like FT-lymphoid-I, has some selectivity for lymphoid tissues and has the advantage that it can be delivered within the time constraints of ex vivo organ preservation.
- Research Organization:
- Univ. of Kansas Medical Center, Kansas City, MO
- OSTI ID:
- 6525323
- Journal Information:
- Transplant. Soc., Int. Cong., Proc.; (United States), Vol. 13:1; Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 29 Jun 1980
- Country of Publication:
- United States
- Language:
- English
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GRAFTS
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
TOLERANCE
WHOLE-BODY IRRADIATION
EVALUATION
BONE MARROW CELLS
FRACTIONATED IRRADIATION
MICE
SKIN
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
TRANSPLANTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals