Role of bone marrow cells in the growth inhibition of transplanted methylcholanthrene-induced sarcoma (MCA). [/sup 137/Cs]
The operation of various antitumor mechanisms in vivo remains largely unknown. The presence of specific sensitized cells in the spleen and lymph node of tumor-bearing and tumor-immune animals has been demonstrated. Such cells are more effectively revealed by secondary sensitization of the splenocytes of tumor-immune animals in vitro by reexposing them to the tumor. Tumor-immune in vitro sensitized splenocytes (ISS) are highly effective in retarding the in vivo growth of the sensitizing tumor when they are transplated together with tumor cells into normal recipient mice. However, if the same cell transfer is made into lethally irradiated mice, the tumor will grow rapidly in 100% of recipients. The objective of the present study is to explore this phenomenon and to determine the origin of the host cells that are capable of collaborating with tumor-immune in vitro sensitized splenocytes in the regulation of tumor growth. We designed experiments to test whether the host cells involved in tumor growth regulation are derived from the spleen, thymus, or the bone marrow and set out to determine whether or not collaboration of the host cells with ISS was specific as far as the sensitizing tumor was concerned.
- Research Organization:
- Univ. of Washington, Seattle
- DOE Contract Number:
- EY-76-S-06-2225
- OSTI ID:
- 6525299
- Journal Information:
- Transplant. Soc., Int. Cong., Proc.; (United States), Vol. 13:1; Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 29 Jun 1980
- Country of Publication:
- United States
- Language:
- English
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CELL KILLING
RADIOINDUCTION
GROWTH
INHIBITION
SARCOMAS
STRONTIUM 88
COMPARATIVE EVALUATIONS
STRONTIUM 89
WHOLE-BODY IRRADIATION
CESIUM 137
GAMMA RADIATION
LETHAL IRRADIATION
MICE
SPLEEN CELLS
STRONTIUM CHLORIDES
THYMOCYTES
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CESIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
STABLE ISOTOPES
STRONTIUM COMPOUNDS
STRONTIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
560162 - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells