Structure-activity comparison of hydrazine to other Nasotoxic chemicals. Final report, August-October 1991
The biotransformation of 19 chemicals that have caused nasal epithelial toxicity in-long-term carcinogenesis experiments in laboratory rodents was compared with the biotransformation of hydrazine, in order to determine if these chemicals share common metabolic pathways. Ten of the 19 chemicals were tumorigenic; four were epoxides or epoxide-formers; three were metabolized to reactive aldehydes; and one was metabolized to a lactone ring. The two remaining chemicals, p-cresidene and 2,6-xylidene, possess an amino group that can undergo biotransformation to reactive metabolites in a way similar to hydrazine, but there is no evidence to support this hypothesis. Therefore, none of the 19 chemicals are metabolized in a way similar to hydrazine.... Structure-activity, Hydrazine, Nasotoxicity, Carcinogenicity.
- Research Organization:
- ManTech Environmental Technology, Inc., Dayton, OH (United States)
- OSTI ID:
- 6524235
- Report Number(s):
- AD-A-262588/7/XAB; CNN: F33615-90-C-0532
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HYDRAZINE
TOXICITY
ALDEHYDES
ANATOMY
BIOLOGY
CARCINOGENESIS
EPITHELIUM
EPOXIDES
HALOGEN COMPOUNDS
HYPOTHESIS
LABORATORIES
LACTONES
METABOLISM
METABOLITES
METHACRYLATES
MOLECULAR STRUCTURE
NOSE
RODENTS
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSFORMATIONS
ANIMAL TISSUES
ANIMALS
BODY
BODY AREAS
CARBOXYLIC ACID SALTS
ESTERS
FACE
HEAD
HETEROCYCLIC COMPOUNDS
MAMMALS
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOGENESIS
RESPIRATORY SYSTEM
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology