Dietary fibers and heavy metal retention in the rat
The metal-binding capacities of some gel-forming polysaccharides and other substances have been investigated in vitro in an attempt to relate their metal-binding properties to the retention of dietary Pb and Cd in vivo. In equilibrium dialysis systems, aqueous solutions of alginic acid, pectin, agar, and carrageenan (1 g fiber/100 ml) all bound Pb and Cd to varying degrees. Alginic acid had the greatest binding capacity for Pb (50 ..mu..g Pb bound/mg fiber) and carrageenan for Cd (9.3 ..mu..g Cd bound/mg fiber). Addition of any one of these fibers, or indulin or glucuronic acid to the diet increased the tissue retention of one or both of the metals. Only cellulose supplementation reduced the retention of both Pb and Cd. Carrageenan decreased that of Pb and increased that of Cd. In another experiment alginic acid was shown to increased Pb retention in rats even when present at fairly low dietary concentrations (1 g/kg).
- Research Organization:
- Rowett Research Institute, Aberdeen, Scotland
- OSTI ID:
- 6523393
- Journal Information:
- Environ. Res.; (United States), Vol. 42:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Influence of diet or intrarectal bile acid injections on colon epithelial cell proliferation in rats previously injected with 1,2-dimethylhydrazine
Microbial extracellular polysaccharides and plagioclase dissolution
Related Subjects
AGAR
BIOLOGICAL EFFECTS
ALGINIC ACID
CADMIUM
RETENTION
CELLULOSE
LEAD
PECTINS
DIET
RATS
ANIMALS
BLOOD SUBSTITUTES
CARBOHYDRATES
COLLOIDS
DISPERSIONS
DRUGS
ELEMENTS
HEMATOLOGIC AGENTS
MAMMALS
METALS
ORGANIC COMPOUNDS
POLYSACCHARIDES
RODENTS
SACCHARIDES
VERTEBRATES
550500* - Metabolism