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Title: [sup 222]Rn dosimetry in the dog lung

[sup 222]Rn dosimetry in the dog lung The alpha dose to cells in bronchial airways in the beagle dog during historical exposures to [sup 222]Rn decay products is calculated using updated information on airway morphometry, call nucleus depth, mucus thickness, physical dosimetry and atmospheric characteristics. The alpha dose per unit exposure to basal call nuclei in the upper airways ranges from 2 to 7 mGy WLM[sup [minus]1] (excluding the trachea) depending upon the exposure protocol used. The dose to alveolar tissue is 3 mGy WLM[sup [minus]1]. In the human lung, the dose factor for the bronchial airways is 9 mGy WLM[sub [minus]1] and for the pulmonary parenchyma 0.5 mGy WLM[sup [minus]1] The human tumors appear primarily in the first few branching airway generations while the only tumors observed in the animals were in the bronchioloalveolar region suggesting a difference in cell sensitivity to alpha radiation.
Authors: ; ;
Publication Date:
OSTI Identifier:6522531
Report Number(s):CONF-910905-5
ON: DE93014035
DOE Contract Number:FG02-87ER60547
Resource Type:Conference
Data Type:
Resource Relation:Conference: 5. international symposium on the natural radiation environment, Salzburg (Austria), 22-28 Sep 1991
Research Org:New York Univ., NY (United States). School of Medicine
Sponsoring Org:DOE; USDOE, Washington, DC (United States)
Country of Publication:United States
Language:English
Subject: 61 RADIATION PROTECTION AND DOSIMETRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRONCHI; RADIATION DOSES; LUNGS; RESPIRATORY TRACT CELLS; ALPHA DOSIMETRY; DAUGHTER PRODUCTS; DOGS; RADON 222; ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; ANIMALS; BODY; DAYS LIVING RADIOISOTOPES; DOSES; DOSIMETRY; EVEN-EVEN NUCLEI; HEAVY NUCLEI; ISOTOPES; MAMMALS; NUCLEI; ORGANS; RADIOISOTOPES; RADON ISOTOPES; RESPIRATORY SYSTEM; VERTEBRATES 560101* -- Biomedical Sciences, Applied Studies-- Radiation Effects-- Dosimetry & Monitoring-- (1992-); 560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells