skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radiation-induced interphase death observed in human T-cell lymphoma cells established as a nude mouse tumor line

Abstract

Interphase death of cells occurs physiologically in healthy animal tissues as well as in tissues pathologically injured by radiation or drugs. An active self-destruction process has been found to play a major role in the interphase death of highly radiosensitive cells. However, the mechanism of this radiation-induced interphase death in human lymphoma has not yet been studied in detail. In the present study, we examined a lymphoma derived from a child lymphoblastic lymphoma bearing CD1, CD4, and CD8 antigens and established in nude mice. Low-dose x-irradiation of this lymphoma induced interphase cell death with characteristic morphological and biological changes of an active self-destruction process, i.e., changes in cell surface appearance seen using scanning electron microscopy and nuclear fragmentation accompanied with an increase in free DNA. The process was proved to require protein synthesis. It was concluded that the radiosensitivity of this T-cell lymphoma of common thymic type is mainly due to the occurrence of the active self-destruction process.

Authors:
; ;  [1]
  1. Univ. of Chiba School of Medicine (Japan)
Publication Date:
OSTI Identifier:
6521364
Resource Type:
Journal Article
Journal Name:
Experimental Hematology (Lawrence, Kansas); (USA)
Additional Journal Information:
Journal Volume: 18:7; Journal ID: ISSN 0301-472X
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; TUMOR CELLS; RADIOSENSITIVITY; CELL CYCLE; CELL FLOW SYSTEMS; DNA; EXPERIMENTAL NEOPLASMS; LOW DOSE IRRADIATION; LYMPHOCYTES; LYMPHOMAS; MAN; MICE; SCANNING ELECTRON MICROSCOPY; THYMUS; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; ELECTRON MICROSCOPY; IMMUNE SYSTEM DISEASES; IONIZING RADIATIONS; IRRADIATION; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; MICROSCOPY; NEOPLASMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture

Citation Formats

Igarashi, T, Yoshida, S, and Miyamoto, T. Radiation-induced interphase death observed in human T-cell lymphoma cells established as a nude mouse tumor line. United States: N. p., 1990. Web.
Igarashi, T, Yoshida, S, & Miyamoto, T. Radiation-induced interphase death observed in human T-cell lymphoma cells established as a nude mouse tumor line. United States.
Igarashi, T, Yoshida, S, and Miyamoto, T. 1990. "Radiation-induced interphase death observed in human T-cell lymphoma cells established as a nude mouse tumor line". United States.
@article{osti_6521364,
title = {Radiation-induced interphase death observed in human T-cell lymphoma cells established as a nude mouse tumor line},
author = {Igarashi, T and Yoshida, S and Miyamoto, T},
abstractNote = {Interphase death of cells occurs physiologically in healthy animal tissues as well as in tissues pathologically injured by radiation or drugs. An active self-destruction process has been found to play a major role in the interphase death of highly radiosensitive cells. However, the mechanism of this radiation-induced interphase death in human lymphoma has not yet been studied in detail. In the present study, we examined a lymphoma derived from a child lymphoblastic lymphoma bearing CD1, CD4, and CD8 antigens and established in nude mice. Low-dose x-irradiation of this lymphoma induced interphase cell death with characteristic morphological and biological changes of an active self-destruction process, i.e., changes in cell surface appearance seen using scanning electron microscopy and nuclear fragmentation accompanied with an increase in free DNA. The process was proved to require protein synthesis. It was concluded that the radiosensitivity of this T-cell lymphoma of common thymic type is mainly due to the occurrence of the active self-destruction process.},
doi = {},
url = {https://www.osti.gov/biblio/6521364}, journal = {Experimental Hematology (Lawrence, Kansas); (USA)},
issn = {0301-472X},
number = ,
volume = 18:7,
place = {United States},
year = {Wed Aug 01 00:00:00 EDT 1990},
month = {Wed Aug 01 00:00:00 EDT 1990}
}