skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Effects of ultraviolet radiation on the production of epidermal derived thymocyte-activating factor/interleukin-1

Abstract

The effect of both a single exposure and multiple exposures to ultraviolet radiation (UVR) on the production and/or release of epidermal cell derived thymocyte activating factor/interleukin-1 (ETAF/IL-1) were investigated. A single exposure to UVR enhances the release of ETAF/IL-1 both in vitro and in vivo. This conclusion was based on the observation that: (1) in vitro UV-irradiation of the keratinocyte cell line elevated the release of ETAF/IL-1 on a per cell basis; (2) exposure of animals to UVR stimulated a number of in vivo biologic responses which are known to be mediated by ETAF/IL-1; and (3) ETAF/IL-1 could be detected in the serum of UVR exposed but not normal animals. Exposure of mice to UV-irradiation on a daily basis induced a desensitized state in which animals were found to be refractory to further stimulation with this inflammatory agent. A similar desensitization or tolerance was also shown to be induced by multiple intraperitoneal injections of bacterial lipopolysaccharide (LPS). Desensitization, induced by either LPS or UVR, was found to be regulated at the site of interaction between the cells capable of ETAF/IL-1 production and the exogenous inflammatory stimulus. The results indicate that the regulatory mechanisms for ETAF/IL-1 production which are employed bymore » the keratinocyte are distinct from those regulating ETAF/Il-1 production by the macrophage.« less

Authors:
Publication Date:
Research Org.:
Utah Univ., Salt Lake City (USA)
OSTI Identifier:
6520091
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph. D.)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; THYMOCYTES; BIOLOGICAL RADIATION EFFECTS; CHEMICAL ACTIVATION; BIOCHEMISTRY; EPIDERMIS; IN VITRO; IN VIVO; MACROPHAGES; MICE; ULTRAVIOLET RADIATION; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CHEMISTRY; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; EPITHELIUM; MAMMALS; ORGANS; PHAGOCYTES; RADIATION EFFECTS; RADIATIONS; RODENTS; SKIN; SOMATIC CELLS; TISSUES; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture

Citation Formats

Gahring, L C. Effects of ultraviolet radiation on the production of epidermal derived thymocyte-activating factor/interleukin-1. United States: N. p., 1986. Web.
Gahring, L C. Effects of ultraviolet radiation on the production of epidermal derived thymocyte-activating factor/interleukin-1. United States.
Gahring, L C. 1986. "Effects of ultraviolet radiation on the production of epidermal derived thymocyte-activating factor/interleukin-1". United States.
@article{osti_6520091,
title = {Effects of ultraviolet radiation on the production of epidermal derived thymocyte-activating factor/interleukin-1},
author = {Gahring, L C},
abstractNote = {The effect of both a single exposure and multiple exposures to ultraviolet radiation (UVR) on the production and/or release of epidermal cell derived thymocyte activating factor/interleukin-1 (ETAF/IL-1) were investigated. A single exposure to UVR enhances the release of ETAF/IL-1 both in vitro and in vivo. This conclusion was based on the observation that: (1) in vitro UV-irradiation of the keratinocyte cell line elevated the release of ETAF/IL-1 on a per cell basis; (2) exposure of animals to UVR stimulated a number of in vivo biologic responses which are known to be mediated by ETAF/IL-1; and (3) ETAF/IL-1 could be detected in the serum of UVR exposed but not normal animals. Exposure of mice to UV-irradiation on a daily basis induced a desensitized state in which animals were found to be refractory to further stimulation with this inflammatory agent. A similar desensitization or tolerance was also shown to be induced by multiple intraperitoneal injections of bacterial lipopolysaccharide (LPS). Desensitization, induced by either LPS or UVR, was found to be regulated at the site of interaction between the cells capable of ETAF/IL-1 production and the exogenous inflammatory stimulus. The results indicate that the regulatory mechanisms for ETAF/IL-1 production which are employed by the keratinocyte are distinct from those regulating ETAF/Il-1 production by the macrophage.},
doi = {},
url = {https://www.osti.gov/biblio/6520091}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1986},
month = {Wed Jan 01 00:00:00 EST 1986}
}

Thesis/Dissertation:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this thesis or dissertation.

Save / Share: