In vivo effects of nickel and cadmium in rats on lipid peroxidation and ceruloplasmin activity
- Univ. of Barcelona, Tarragona (Spain)
Before Ni(II) and Cd(II), or any other metallic ion, can interact intracellulary, it must penetrate the cell membrane. The latter, therefore, is a primary target for toxic metals. Damage to cell membranes may allow a greater uptake of metal and thus injury may extend to more critical targets, although loss of plasmatic membrane functionality may be a crucial factor to explain the interactions of these metals with cellular components. In this sense the present study has been carried out. Factors that have been investigated in order to prove the membrane response of nickel and cadmium toxicity include lipid peroxidation, since divalent ions of transition metals can promote lipid peroxidation and this evidently contributes to the toxicity of certain metals and to metal interaction with ceruloplasmin, as its ferroxidase and scavenger of superoxide radicals activities are important protective mechanisms in vivo against peroxidative damage.
- OSTI ID:
- 6519180
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 44:5; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM CHLORIDES
BIOLOGICAL EFFECTS
CERULOPLASMIN
BIOCHEMISTRY
LIPIDS
OXIDATION
NICKEL CHLORIDES
IN VIVO
RATS
ANIMALS
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHEMICAL REACTIONS
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
COMPLEXES
COPPER COMPLEXES
GLOBULINS
GLOBULINS-ALPHA
HALIDES
HALOGEN COMPOUNDS
MAMMALS
METALLOPROTEINS
NICKEL COMPOUNDS
ORGANIC COMPOUNDS
PROTEINS
RODENTS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology