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Title: Response of the mediastinal and thoracic viscera of the dog to intraoperative radiation therapy (IORT)

Abstract

IORT may be a potentially useful adjunctive treatment combined with surgery and/or external beam irradiation in treating locally advanced lung and esophageal tumors. To begin investigation of this modality, the tolerance of intact mediastinal structures to IORT was studied using adult American Foxhounds (wt. 25-30 kg). Groups of six animals received IORT to doses of 20, 30, or 40 Gy to two separate intrathoracic ports, using 9 MeV electrons to treat a portion of the collapsed right upper lobe, and 12 MeV electrons to treat the mediastinal structures. A group of three dogs received thoracotomy with sham irradiation. Two dogs from each treatment dose group, as well as one sham-irradiated control, were sacrificed electively at 1, 3, and 12 months following IORT. There were no acute nor late IORT related mortalities. Post-operative weight loss was minimal (average 4.5% of pre-operative weight) for all dogs. Serial esophagrams showed no inflammation or ulceration. No cardiac nor pulmonary changes were noted clinically. At autopsy, the irradiated lung showed evidence of acute pneumonitis at 1 month with progressive fibrosis at 3 months and 1 year. Esophageal reactions were minimal, with only two dogs (one 30 Gy and one 40 Gy) demonstrating histologically confirmed esophagitismore » at 1 month. Tracheal changes were minimal. Cardiac damage was evident in the right atrial tissues. In several dogs, this cardiac damage ranged from myocardial vascular changes to frank ischemic necrosis noted at 1 and 3 months, and dense fibrosis at 1 year. The phrenic nerves showed normal function, but had evidence of perineural fibrosis. The large vessels demonstrated only mild histologic evidence of irradiation. The results of this large animal study suggest that intact mediastinal structures will tolerate small volume IORT to doses of 20 Gy without significant clinical sequellae. (Abstract Truncated)« less

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
National Cancer Institute, Bethesda, MD
OSTI Identifier:
6519097
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ESOPHAGUS; NEOPLASMS; LUNGS; RADIOTHERAPY; SIDE EFFECTS; AORTA; DOGS; NECROSIS; PNEUMONITIS; RADIATION DOSES; RADIATION INJURIES; RADIOSENSITIVITY; SURGERY; TRACHEA; ANIMALS; ARTERIES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DIGESTIVE SYSTEM; DISEASES; DOSES; INJURIES; MAMMALS; MEDICINE; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; VERTEBRATES; 550603* - Medicine- External Radiation in Therapy- (1980-); 560152 - Radiation Effects on Animals- Animals

Citation Formats

Barnes, M, Pass, H, DeLuca, A, Tochner, Z, Potter, D, Terrill, R, Sindelar, W F, and Kinsella, T J. Response of the mediastinal and thoracic viscera of the dog to intraoperative radiation therapy (IORT). United States: N. p., 1987. Web. doi:10.1016/0360-3016(87)90011-3.
Barnes, M, Pass, H, DeLuca, A, Tochner, Z, Potter, D, Terrill, R, Sindelar, W F, & Kinsella, T J. Response of the mediastinal and thoracic viscera of the dog to intraoperative radiation therapy (IORT). United States. https://doi.org/10.1016/0360-3016(87)90011-3
Barnes, M, Pass, H, DeLuca, A, Tochner, Z, Potter, D, Terrill, R, Sindelar, W F, and Kinsella, T J. 1987. "Response of the mediastinal and thoracic viscera of the dog to intraoperative radiation therapy (IORT)". United States. https://doi.org/10.1016/0360-3016(87)90011-3.
@article{osti_6519097,
title = {Response of the mediastinal and thoracic viscera of the dog to intraoperative radiation therapy (IORT)},
author = {Barnes, M and Pass, H and DeLuca, A and Tochner, Z and Potter, D and Terrill, R and Sindelar, W F and Kinsella, T J},
abstractNote = {IORT may be a potentially useful adjunctive treatment combined with surgery and/or external beam irradiation in treating locally advanced lung and esophageal tumors. To begin investigation of this modality, the tolerance of intact mediastinal structures to IORT was studied using adult American Foxhounds (wt. 25-30 kg). Groups of six animals received IORT to doses of 20, 30, or 40 Gy to two separate intrathoracic ports, using 9 MeV electrons to treat a portion of the collapsed right upper lobe, and 12 MeV electrons to treat the mediastinal structures. A group of three dogs received thoracotomy with sham irradiation. Two dogs from each treatment dose group, as well as one sham-irradiated control, were sacrificed electively at 1, 3, and 12 months following IORT. There were no acute nor late IORT related mortalities. Post-operative weight loss was minimal (average 4.5% of pre-operative weight) for all dogs. Serial esophagrams showed no inflammation or ulceration. No cardiac nor pulmonary changes were noted clinically. At autopsy, the irradiated lung showed evidence of acute pneumonitis at 1 month with progressive fibrosis at 3 months and 1 year. Esophageal reactions were minimal, with only two dogs (one 30 Gy and one 40 Gy) demonstrating histologically confirmed esophagitis at 1 month. Tracheal changes were minimal. Cardiac damage was evident in the right atrial tissues. In several dogs, this cardiac damage ranged from myocardial vascular changes to frank ischemic necrosis noted at 1 and 3 months, and dense fibrosis at 1 year. The phrenic nerves showed normal function, but had evidence of perineural fibrosis. The large vessels demonstrated only mild histologic evidence of irradiation. The results of this large animal study suggest that intact mediastinal structures will tolerate small volume IORT to doses of 20 Gy without significant clinical sequellae. (Abstract Truncated)},
doi = {10.1016/0360-3016(87)90011-3},
url = {https://www.osti.gov/biblio/6519097}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 3,
place = {United States},
year = {Sun Mar 01 00:00:00 EST 1987},
month = {Sun Mar 01 00:00:00 EST 1987}
}